Silibinin inhibits ultraviolet B radiation‐induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/−) mouse model of basal cell carcinoma

Around 80% of nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC), still studies evaluating the efficacy of chemopreventive agents during early stage/s of BCC development are lacking. Accordingly, utilizing the well‐established patched (Ptch)+/− mouse model of ultraviolet B (UVB) radiation‐induced BCC formation, we excised skin samples from UVB exposed Ptch+/− and Ptch+/+ mice before tumor formation to study the promotion/progression...