Molecular Carcinogenesis
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Papers 3549
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#1Hao Rong (NBU: Ningbo University)
#2Yanguo Li (NBU: Ningbo University)
Last. Meng Ye (NBU: Ningbo University)
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Enhancer RNAs (eRNAs) are a subclass of long noncoding RNAs (lncRNAs) that have a wide effect in human tumors. However, the systematic analysis of potential functions of eRNAs-related genes (eRGs) in colon cancer (CC) remains unexplored. In this study, a total of 8231 eRGs including 6236 protein-coding genes and 1995 lncRNAs were identified in CC based on the multiple resources. These eRGs showed higher expression level and stability compared to other genes. What's more, the functions of these e...
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#1Ellen A. Rorke (UMB: University of Maryland, Baltimore)H-Index: 18
#2Gautam Adhikary (UMB: University of Maryland, Baltimore)H-Index: 20
Last. Richard L. Eckert (UMB: University of Maryland, Baltimore)H-Index: 55
view all 10 authors...
Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct and mutually exclusive activity. The closed conformation has GTP-binding/GTPase activity while the open conformation functions as a transamidase to catalyze protein-protein crosslinking. GTP-binding/GTPase activity is required for TG2 maintenance of the aggressive cancer phe...
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#1Maksudul Alam (LSU Health Sciences Center Shreveport)H-Index: 8
#2Janmaris Marin Fermin (LSU Health Sciences Center Shreveport)
Last. Cherie-Ann O. Nathan (LSU Health Sciences Center Shreveport)H-Index: 30
view all 9 authors...
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts. Rapalogs significantly reduced cell viability and colony formation. Interestingly, rapalogs...
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#1Ekaterina Laukhtina (Medical University of Vienna)H-Index: 7
#2Victor M. Schuettfort (UHH: University of Hamburg)H-Index: 5
Last. Nico С. Grossmann (UZH: University of Zurich)
view all 23 authors...
Elevated preoperative plasma level of endoglin has been associated with worse oncologic outcomes in various malignancies. The present large-scale study aimed to determine the predictive and prognostic values of preoperative endoglin with regard to clinicopathologic and survival outcomes in patients treated with radical cystectomy (RC) for nonmetastatic urothelial carcinoma of the bladder (UCB). We prospectively collected preoperative blood samples from 1036 consecutive patients treated with RC f...
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#1Laurel Darragh (University of Colorado Denver)H-Index: 5
#2Sana D. Karam (University of Colorado Denver)H-Index: 25
Presentation of tumor antigens is a critical step in producing a robust antitumor immune response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T cells by professional antigen-presenting cells (pAPCs) like dendritic cells using major histocompatibility complexes (MHC) I and II. But recent evidence suggests that in the tumor microenvironment (TME) cells other than pAPCs are capable of presenting tumor antigens on both MHC I and II. The evidence currently available on...
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#1Deri Morgan (KU: University of Kansas)H-Index: 1
#2Kiersten L. Berggren (UNM: University of New Mexico)H-Index: 6
Last. Gregory N Gan (KU: University of Kansas)H-Index: 1
view all 9 authors...
Cancer and the immune system share an intimate relationship. Chronic inflammation increases the risk of cancer occurrence and can also drive inflammatory mediators into the tumor microenvironment enhancing tumor growth and survival. The p38 MAPK pathway is activated both acutely and chronically by stress, inflammatory chemokines, chronic inflammatory conditions, and cancer. These properties have led to extensive efforts to find effective drugs targeting p38, which have been unsuccessful. The imm...
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#1Zheng Wu (Hebei Medical University)H-Index: 1
#2Yan Li (Hebei Medical University)H-Index: 49
Last. Wei Guo (Hebei Medical University)H-Index: 21
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The transcription factor forkhead box D3 (FOXD3) is an important member of the FOX family, which can maintain the pluripotent properties of cell clusters, neural crest, and trophoblastic progenitor cells in vivo. It has been shown that FOXD3 could affect proliferation, migration, and angiogenesis of various tumors and its deletion and overexpression in organisms will undoubtedly have important influence on the change of cell fate and the occurrence of tumors. However, the underlying functions an...
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Cellular senescence is a well-documented response to oncogene activation in many tissues. Multiple pathways are invoked to achieve senescence indicating its importance to counteract the transforming activities of oncogenic stimulation. We now report that the Rho-associated protein kinase (ROCK) signaling pathway is a critical regulator of oncogene-induced senescence in skin carcinogenesis. Transformation of mouse keratinocytes with oncogenic RAS upregulates ROCK activity and initiates a senescen...
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#1Eric L Bolf (UVM: University of Vermont)H-Index: 3
#2Noelle E Gillis (UVM: University of Vermont)H-Index: 3
Last. Frances E. Carr (UVM: University of Vermont)H-Index: 16
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The thyroid hormone receptor beta (TRβ) is a tumor suppressor in multiple types of solid tumors, most prominently in breast and thyroid cancer. An increased understanding of the molecular mechanisms by which TRβ abrogates tumorigenesis will aid in understanding the core tumor-suppressive functions of TRβ. Here, we restored TRβ expression in the MDA-MB-468 basal-like breast cancer cell line and perform RNA-sequencing to determine the TRβ-mediated changes in gene expression and associated signalin...
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#1Carly S. Wilder (University of Texas at Austin)
#2Zhao Chen (University of Texas at Austin)
Last. John DiGiovanni (University of Texas at Austin)H-Index: 70
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Cancer cells undergo metabolic reprogramming to support increased demands in bioenergetics and biosynthesis and to maintain reactive oxygen species at optimum levels. As metabolic alterations are broadly observed across many cancer types, metabolic reprogramming is considered a hallmark of cancer. A metabolic alteration commonly seen in cancer cells is an increased demand for certain amino acids. Amino acids are involved in a wide range of cellular functions, including proliferation, redox balan...
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