A DIRECT REGULATORY LINK BETWEEN MICRORNA MIR-137 AND SHANK2 WITH IMPLICATIONS FOR NEUROPSYCHIATRIC DISORDERS
Abstract
The SHANK gene family encodes for postsynaptic scaffolding proteins with an important role at glutamatergic synapses in the brain and has been linked to a spectrum of neurodevelopmental disorders. The schizophrenia associated microRNA miR-137 and the SHANK genes converge on several levels, (a) both are expressed at the synapse, (b) both influence neuronal development, and (c) both have a strong link to neurodevelopmental and neuropsychiatric...
Paper Details
Title
A DIRECT REGULATORY LINK BETWEEN MICRORNA MIR-137 AND SHANK2 WITH IMPLICATIONS FOR NEUROPSYCHIATRIC DISORDERS
Published Date
Jan 1, 2019
Volume
29
Pages
S872 - S873
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