European Neuropsychopharmacology
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4.60
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29.7k
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#1Martijn Arns (UM: Maastricht University)H-Index: 46
#2Hanneke van Dijk (UM: Maastricht University)
Last. Sebastian OlbrichH-Index: 20
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Here we review the paradigm-change from one-size-fits-all psychiatry to more personalized-psychiatry, where we distinguish between 'precision psychiatry' and 'stratified psychiatry'. Using examples in Depression and ADHD we argue that stratified psychiatry, using biomarkers to facilitate patients to best 'on-label' treatments, is a more realistic future for implementing biomarkers in clinical practice.
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#1Mark Horowitz (UCL: University College London)H-Index: 13
#2David Taylor (South London and Maudsley NHS Foundation Trust)H-Index: 168
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#1Benjamin I. Goldstein (CAMH: Centre for Addiction and Mental Health)H-Index: 7
#2Bradley J. MacIntosh (Sunnybrook Research Institute)H-Index: 34
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#1Paolo Fusar-Poli (South London and Maudsley NHS Foundation Trust)H-Index: 98
#2Ziggi Ivan Santini (SDU: University of Southern Denmark)H-Index: 14
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#1Mario Gennaro Mazza (Vita-Salute San Raffaele University)H-Index: 7
#2Raffaella Zanardi (Vita-Salute San Raffaele University)H-Index: 39
Last. Francesco Benedetti (Vita-Salute San Raffaele University)H-Index: 70
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The spreading of the Severe Acute Respiratory Syndrome Coronavirus (COVID-19) pandemic could be associated with psychiatric implications. After COVID-19, depression was reported in 40% of patients at one-, three-, and six-months follow-up. Emerging literature suggests anti-inflammatory and antiviral properties of antidepressants in the treatment of SARS-CoV-2. We aim to investigate the efficacy of Selective Serotonin Reuptake Inhibitor (SSRI) in treating post-COVID depression. We included 60 pat...
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#1Talwinder Gill (CAMH: Centre for Addiction and Mental Health)
#2Sarah E Watling (CAMH: Centre for Addiction and Mental Health)
Last. Shawn G. Rhind (DRDC: Defence Research and Development Canada)H-Index: 32
view all 14 authors...
Abstract null null Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that results from exposure to traumatic event(s). Decreased astrocyte-related proteins (e.g., glial fibrillary acidic protein, GFAP) and atrophic astrocytes in corticolimbic brain areas implicated in PTSD have been reported in experimental models suggesting that astrocyte pathology may be a feature of this disorder. We used positron emission tomography (PET) of the monoamine oxidase (MAO)-B probe [1...
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#1Laura Xicota (Allen Institute for Brain Science)H-Index: 1
#2Ilario De TomaH-Index: 4
Last. Mara Dierssen (UPF: Pompeu Fabra University)H-Index: 61
view all 9 authors...
Pharmacotranscriptomics is a still very new field of research that has just begun to flourish and promises to enable target discovery, inform biomarker and evaluate drug efficacy beyond pharmacogenomics. The aim of this review is to provide a critical overview of the biological foundations of transcriptomics, methodological approaches to transcriptomic studies, and their advantages and limitations. We present the different RNA species (rRNAs, tRNAs, mtRNAs, snRNAs, scRNAs, mRNAs, ncRNAs, LINE an...
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#1Konstantinos N. Fountoulakis (Aristotle University of Thessaloniki)H-Index: 60
#2Grigorios N. Karakatsoulis (Aristotle University of Thessaloniki)H-Index: 1
Last. Sarah Bjedov (KBC: University Hospital Centre Zagreb)H-Index: 3
view all 157 authors...
Abstract null null Introduction null There are few published empirical data on the effects of COVID‐19 on mental health, and until now, there is no large international study. null null null Material and methods null During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previ...
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#1Katherine E. Burdick (BWH: Brigham and Women's Hospital)H-Index: 58
#2Caitlin E. Millett (BWH: Brigham and Women's Hospital)H-Index: 6
Abstract null null Bipolar disorder (BD) is a complex illness with variability at the level of symptom presentation, clinical course, cognitive capacity, and everyday function. Cognition is a key predictor of functional disability in BD, however, much remains unknown about the development and presentation of cognitive dysfunction in BD. Studies have shown that 30-50% of affectively stable people with BD are indistinguishable from healthy individuals in terms of cognitive presentation. In contras...
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#1Joe Kwun Nam Chan (HKU: University of Hong Kong)H-Index: 4
#2Corine Sau Man Wong (HKU: University of Hong Kong)H-Index: 9
Last. Wing Chung Chang (HKU: University of Hong Kong)H-Index: 26
view all 5 authors...
Abstract null null Schizophrenia is associated with increased prevalence of diabetes. However, risk of diabetes complications as well as the impact of complication burden and patterns on subsequent mortality risk in schizophrenia patients with co-existing diabetes is understudied. This population-based, propensity-score matched (1:10) cohort study identified 6991 patients with incident diabetes and pre-existing schizophrenia and 68,682 patients with incident diabetes only (comparison group) betw...
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