Relationship among obesity, insulin resistance, and hyperinsulinemia in the polycystic ovary syndrome

Published on Mar 21, 2019in Endocrine3.235
· DOI :10.1007/S12020-019-01899-9
Michael H. Dahan20
Estimated H-index: 20
(McGill University),
Gerald M. Reaven148
Estimated H-index: 148
(Stanford University)
Sources
Abstract
Purpose To evaluate the relationship between obesity and insulin resistance among women with polycystic ovary syndrome (PCOS) using a gold standard test.
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References11
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#1Joshua W. Knowles (Stanford University)H-Index: 53
#2Themistocles L. Assimes (Stanford University)H-Index: 81
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Background Two direct measurements of peripheral insulin sensitivity are the M value derived from the euglycemic, hyperinsulinemic clamp (EC) and the steady-state plasma glucose (SSPG) concentration derived from the insulin suppression test (IST). Prior work suggests that these measures are highly correlated, but the agreement between them is unknown. To determine the agreement between SSPG and M and to develop transformation equations to convert SSPG to M and vice versa, we directly compared th...
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#1Jana VrbikovaH-Index: 25
#2David CibulaH-Index: 59
Last. Jan Škrha (Charles University in Prague)H-Index: 30
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The aim of our study was to compare insulin sensitivity in lean and obese European polycystic ovary syndrome (PCOS) women with lean healthy women. We performed the euglycemic hyperinsulinemic clamp in 83 women with PCOS [53 lean with body mass index (BMI) of 21.5 ± 1.8 kg/m2 and 30 obese with BMI of 29.6 ± 3.7 kg/m2] and in 15 healthy women with BMI of 21.6 ± 1.8 kg/m2 to determine glucose disposal (M) and the insulin sensitivity index (ISI). Statistical evaluation was done using Kruskal-Wallis ...
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#1Fernando Ovalle (UAB: University of Alabama at Birmingham)H-Index: 30
#2Ricardo Azziz (UAB: University of Alabama at Birmingham)H-Index: 93
Abstract Objective: To review the definition and prevalence of two insulin resistance (IR)-associated phenotypes, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, as well as the risk and nature of their simultaneous presentation. Design: Review of published literature. Result(s): Insulin resistance affects between 10% and 25% of the general population. Two common disorders frequently associated with IR are PCOS, affecting 4% to 6% of reproductive-aged women, and type 2 diabetes mel...
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#1Saip ToprakH-Index: 1
#2Arif YönemH-Index: 7
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Objectives: Most patients with polycystic ovary syndrome (PCOS) are obese and known to have insulin resistance. Obesity per se is a cause of insulin resistance. This study was perfo
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#1Jan Holte (Uppsala University)H-Index: 23
#2T Bergh (Uppsala University)H-Index: 1
Last. Hans Lithell (Uppsala University)H-Index: 88
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Insulin secretion in response to iv glucose and insulin sensitivity (euglycemic hyperinsulinemic clamp) were evaluated in 49 women with polycystic ovary syndrome (PCOS) [body mass index (BMI), 17.6-37.2 kg/m2] and 42 control subjects (BMI, 18.8-38.1 kg/m2). Seven women with PCOS exhibited glucose intolerance with subnormal insulin secretion. Compared with control subjects, women with PCOS and normal glucose tolerance had an increased (36-56%) insulin increment, not explained by insulin resistanc...
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Many reports have suggested that hyperandrogenaemic patients with the polycystic ovary syndrome (PCOS) may be insulin resistant. However, there have also been suggestions that their insulin resistance may relate to obesity and android fat distribution. To assess whether PCOS induces metabolic disturbances independently of obesity, we studied seven lean patients with PCOS (age, 27.1 +/- 2.0 yr; body mass index, 22.2 +/- 0.78 kg/m2; waist/hip ratio, 0.79 +/- 0.02; fat-free mass, 46.38 +/- 1.13 kg)...
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#1Andrea Dunaif (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 81
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Last. Areta Dobrjansky (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
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Hyperinsulinemia secondary to a poorly characterized disorder of insulin action is a feature of the polycystic ovary syndrome (PCO). However, controversy exists as to whether insulin resistance results from PCO or the obesity that is frequently associated with it. Thus, we determined in vivo insulin action on peripheral glucose utilization (M) and hepatic glucose production (HGP) with the euglycemic glucose-clamp technique in obese ( n = 19) and nonobese ( n = 10) PCO women and age- and body-com...
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#1Gerald M. Reaven (Stanford University)H-Index: 148
Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) and in ∼25% of nonobese individuals with normal oral glucose tolerance. In these conditions, deterioration of glucose tolerance can only be prevented if the β-cell is able to increase its insulin secretory response and maintain a state of chronic hyperinsulinemia. When this goal cannot be achieved, gross decompensation of ...
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#1Andrea Dunaif (CUNY: City University of New York)H-Index: 81
#2John Mandeli (CUNY: City University of New York)H-Index: 9
Last. Areta Dobrjansky (CUNY: City University of New York)H-Index: 8
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We investigated whether obesity was a marker for a neuroendocrinologically distinct form of the polycystic ovary syndrome (PCO). Further, since women with PCO have significantly higher basal and/or glucose-stimulated plasma insulin levels, we also examined the effects of chronic hyperinsulinemia on gonadotropin and gonadal steroid secretion. Ten obese women (nine with acanthosis nigricans) and five nonobese women (one with acanthosis nigricans) with PCO as well as seven obese and six nonobese wo...
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#2Hui WangH-Index: 25
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Insulin resistance (IR) is one of the most common features of polycystic ovary syndrome (PCOS), which is related to obesity. Whether increased anti-Mullerian hormone (AMH) levels in PCOS are involved in the pathogenesis of insulin resistance remains unclear. We investigated serum levels of leptin and AMH along with basic clinical and metabolic parameters in 114 PCOS patients and 181 non-PCOS women. PCOS patients presented higher fasting blood glucose, insulin concentrations and Homeostatic Model...
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#1Haixia Song (SDU: Shandong University)
#2Zhenqing Yu (SDU: Shandong University)
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OBJECTIVE To determine the cutoff values of HOMA-IR for predicting clinical pregnancy rate in normal weight patients during their first IVF. MATERIALS AND METHODS The data was retrospectively analyzed from 329 normal-weight women aged 21-40 years with BMI null 3.15 (OR, 0.018, 95% CI, 0.004-0.081; p 3.15 (OR, 0.15, 95% CI, 0.044-0.507; p 2.2, and a significant cutoff point at HOMA-IR >3.15; with 21.45 ≤ BMI null 1.56 (OR, 0.196, 95% CI, 0.055-0.704).In PCOS with BMI null null 3.15 (OR, 0.186; 95...
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#1I Feferkorn (McGill University)
#1Ido Feferkorn (McGill University)
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STUDY QUESTION Is there is an association between smoking and pregnancy complications in pregnant women with polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER There is an increased risk of developing gestational diabetes mellitus (GDM) among women with PCOS who smoke. WHAT IS KNOWN ALREADY Smokers are at increased risk of developing Type 2 Diabetes Mellitus (DM). Given the common pathophysiology and shared risk factors between type 2 DM and GDM, we sought to assess whether an association betwee...
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#2Ruan Xiangyan (Capital Medical University)
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Objectives This study was conducted to determine impact of insulin resistance using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score and BMI in non-hypoxemic out-patients with COPD on FEV1 using linear and polynomial regressions and to determine their correlation. Methods COPD patients of both genders were included after informed consent. Fasting blood sugar and serum insulin were done to calculate HOMA-IR, which were segregated into two groups of ≥ 3 and Results A total of 273...
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#1Valentina Rodriguez Paris (UNSW: University of New South Wales)H-Index: 4
#2Melissa C Edwards (UNSW: University of New South Wales)H-Index: 5
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Polycystic ovary syndrome (PCOS) is a common and heterogeneous disorder; however, the etiology and pathogenesis of PCOS are poorly understood and current management is symptom-based. Defining the pathogenesis of PCOS traits is important for developing early PCOS detection markers and new treatment strategies. Hyperandrogenism is a defining characteristic of PCOS, and studies support a role for androgen-driven actions in the development of PCOS. Therefore, we aimed to determine the temporal patte...
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#2Agnieszka Łebkowska (UMB: Medical University of Białystok)H-Index: 5
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PURPOSE Insulin resistance is an important factor in the pathogenesis of polycystic ovary syndrome (PCOS), which is associated with higher risk of metabolic syndrome (MetS) and cardiovascular complications. Early atherosclerotic lesions may be diagnosed by ultrasonographic parameters: brachial artery flow-mediated dilation after reactive hyperaemia (FMD) and intima-media thickness of common carotid artery (IMT). The aim of the study was to assess the relation of IMT and FMD with clinical and lab...
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BACKGROUND The triglyceride-glucose (TyG) index, which is a simple surrogate marker of insulin resistance, has been suggested as a contributor of cardiovascular disease. However, evidence on the effect of long-term elevation of the TyG index exposure on myocardial infarction (MI) is limited. The current study aimed to evaluate the association of baseline and long-term elevation of the TyG index exposure with the risk of MI. METHODS A total of 98,849 participants without MI at baseline (2006) wer...
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#1Valentina Rodriguez Paris (UNSW: University of New South Wales)H-Index: 4
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Lifestyle, mainly dietary, interventions are first-line treatment for women with polycystic ovary syndrome (PCOS), but the optimal diet remains undefined. We combined a hyperandrogenized PCOS mouse model with a systematic macronutrient approach, to elucidate the impact of dietary macronutrients on the development of PCOS. We identify that an optimum dietary macronutrient balance of a low protein, medium carbohydrate and fat diet can ameliorate key PCOS reproductive traits. However, PCOS mice dis...
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