Endocrine
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#1Francesca Elli (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 17
#2Giovanna Mantovani (University of Milan)H-Index: 51
Pseudohypoparathyroidism (PHP), the first known post-receptorial hormone resistance, derives from a partial deficiency of the α subunit of the stimulatory G protein (Gsα), a key component of the PTH/PTHrP signaling pathway. Since its first description, different studies unveiled, beside the molecular basis for PHP, the existence of different subtypes and of diseases in differential diagnosis associated with genetic alterations in other genes of the PTH/PTHrP pathway. The clinical and molecular o...
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#1Omar Abdel-Rahman (Cross Cancer Institute)H-Index: 28
OBJECTIVE This study aims to assess the performance of the AJCC 8th staging system for pheochromocytomas and paragangliomas (PPGLs) based on a population-based cohort. METHODS Surveillance, epidemiology, and end results (SEER)-18 registry database was reviewed, and patients with PPGLs diagnosed 2004-2015 were reviewed. AJCC stage for each patient was reconstructed from the collaborative stage dataset. Kaplan-Meier survival estimates according to the AJCC stage were reviewed, and multivariable Co...
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#1Stephen P. Fitzgerald (University of Adelaide)H-Index: 4
#2Nigel G. Bean (University of Adelaide)H-Index: 19
Last. Henrik Falhammar (KI: Karolinska Institutet)H-Index: 31
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Purpose null Recently published papers have demonstrated that particularly in untreated individuals, clinical parameters more often associate with thyroid hormone, particularly free thyroxine (FT4), levels than with thyrotropin (TSH) levels. Clinical and research assessments of the thyroid state of peripheral tissues would therefore be more precise if they were based on FT4 levels rather than on TSH levels. In this paper we describe implications of, and opportunities provided by, this discovery....
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#1K M J A ClaessenH-Index: 11
#1Kim M J A Claessen (Loyola University Medical Center)
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PURPOSE Bone health is compromised in acromegaly resulting in vertebral fractures (VFs), regardless of biochemical remission. Sclerostin is a negative inhibitor of bone formation and is associated with increased fracture risk in the general population. Therefore, we compared sclerostin concentrations between well-controlled acromegaly patients and healthy controls, and assessed its relationship with bone mineral density (BMD), and VFs in acromegaly. METHODS Seventy-nine patients (mean age 58.9 ±...
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#1Cui Li (Fourth Military Medical University)H-Index: 1
#2Guihua Cao (Fourth Military Medical University)H-Index: 3
Last. Xiaoxuan Ning (Fourth Military Medical University)
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Purpose null Cushing's syndrome (CS) is a rare and severe disease caused by sustained hypercortisolism. The clinical manifestations of CS can be atypical in the elderly, and the diagnosis in these patients is often missed. Infectious Purpura Fulminans (PF) is a life-threating, thrombotic form of disseminated intravascular coagulation with high mortality. To our knowledge, PF occurring in a patient with CS has not been reported previously. null Methods null We described an 84-year-old female pres...
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#1Congxin Dai (Capital Medical University)H-Index: 1
#2Ming Feng (Peking Union Medical College Hospital)H-Index: 16
Last. Renzhi Wang (Peking Union Medical College Hospital)H-Index: 23
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OBJECTIVE Transsphenoidal surgery (TSS) is the first-line treatment for patients with Cushing's disease (CD). However, the reported remission rates of patients who received TSS vary widely between different studies, and the predictors of surgical outcomes remain controversial. The present study analyzed the early outcome of TSS in a large population of patients with CD at a single center, and identified potential predictors of initial remission of TSS in patients with CD. METHODS The clinical fe...
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#1José Luis Muñoz de Nova (UAM: Autonomous University of Madrid)H-Index: 5
#2Miguel Sampedro-Núñez (UAM: Autonomous University of Madrid)H-Index: 10
Last. Monica Marazuela Azpiroz (UAM: Autonomous University of Madrid)H-Index: 1
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Normocalcemic primary hyperparathyroidism is an entity on which several issues about its clinical management remains unclear. This is reflected in the main current guidelines, where there are no evidence-based specific recommendations. Through an exhaustive review of current literature, a clinical management algorithm for these patients is proposed. We consider the diagnosis criteria, the differential diagnosis, the clinical manifestations, and the treatment indications. When indicated, we also ...
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#1Matthew Edwards (Case Western Reserve University)H-Index: 1
Last. Juan P. Brito (Mayo Clinic)H-Index: 35
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Purpose null Nearly half the cases of thyroid cancer, a malignancy rapidly rising in incidence within the United States, are attributable to small and asymptomatic papillary thyroid cancers that will not increase mortality. A primary driver of thyroid cancer overdiagnosis is ultrasound use. It is therefore valuable to understand how inappropriate use of thyroid ultrasound is defined, analyze the current evidence for its frequency, and identify interventions to lessen misuse. null Methods null Ov...
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#1Francesca Capriglione (Magna Græcia University)
#2Antonella Verrienti (Sapienza University of Rome)H-Index: 20
Last. Cosimo Durante (Sapienza University of Rome)H-Index: 37
view all 12 authors...
Purpose null In this study, we investigated the profile of microRNAs (miRNAs) contained in exosomes secreted in the serum of patients with papillary thyroid cancer (PTC). null Methods null Exosome were isolated by adding ExoQuick Exosome Precipitation Solution. Dynamic light scattering (DLS) and western blotting analysis were used to ensure the quality of exosomes. The expression levels of miRNAs were investigated using custom-designed TaqMan Advanced miRNA Array Cards in the screening cohort an...
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Endocrinology
Thyroid
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