A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

Differences in the metabolism of cancer cells or cancer stem cells ( CSC s) as compared to normal cells have provided avenues to safely target cancers. To discover metabolic inhibitors of CSC s, we performed alkaline phosphatase‐ and tumoursphere‐based drug screening using induced cancer stem cell‐like cells. From the screening of a RIKEN NPD epo chemical library, we discovered NPD 2381 as a novel and selective cancer‐stemness inhibitor that...