FEBS Letters
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#1Sarika Tilwani (HBNI: Homi Bhabha National Institute)
#2Karan Gandhi (Cancer Research Institute)
Last. Sorab N. Dalal (HBNI: Homi Bhabha National Institute)H-Index: 16
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14-3-3 proteins are conserved, dimeric, acidic proteins that regulate multiple cellular pathways. Loss of either 14-3-3e or 14-3-3γ leads to centrosome amplification. However, we find that while the knockout of 14-3-3e leads to multi-polar mitoses, the knockout of 14-3-3γ results in centrosome clustering and pseudo-bipolar mitoses. 14-3-3γ knockouts demonstrate compromised desmosome function and a decrease in keratin levels, leading to decreased cell stiffness and an increase in centrosome clust...
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#1Camille Ravel-Godreuil (Collège de France)
#2Rania Znaidi (Collège de France)
Last. Julia Fuchs (Collège de France)H-Index: 17
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Neurodegenerative diseases (NDs), including the most prevalent Alzheimer's disease and Parkinson disease, share common pathological features. Despite decades of gene-centric approaches, the molecular mechanisms underlying these diseases remain widely elusive. In recent years, transposable elements (TEs), long considered 'junk' DNA, have gained growing interest as pathogenic players in NDs. Age is the major risk factor for most NDs, and several repressive mechanisms of TEs, such as heterochromati...
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#1David Millrine (Cardiff University)H-Index: 3
#2Robert Hywel Jenkins (Cardiff University)H-Index: 15
Last. Simon Jones (Cardiff University)H-Index: 106
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Unravelling the molecular mechanisms that account for functional pleiotropy is a major challenge for researchers in cytokine biology. Cytokine-receptor cross-reactivity and shared signalling pathways are considered primary drivers of cytokine pleiotropy. However, reports epitomized by studies of Jak-STAT cytokine signalling identify interesting biochemical and epigenetic determinants of transcription factor regulation that affect the delivery of signal-dependent cytokine responses. Here, a regul...
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#1Shawn Freed (Bellevue University)H-Index: 1
#2Danielle S. Baldi (Bellevue University)
Last. Tyler C. Moore (Bellevue University)H-Index: 1
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Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including type I interferon (IFN-I). Secreted IFN-I positively feeds back to amplify antiviral gene expression. In this report, we study the role of MEK/ERK MAP kinase in modulating antiviral gene expression downstream of TLR3. We find MEK/ERK is a negative ...
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#1Francesca Coscia (LMB: Laboratory of Molecular Biology)H-Index: 5
#2Jan Löwe (LMB: Laboratory of Molecular Biology)H-Index: 75
In bacteria, Lon is a large hexameric ATP-dependent protease that targets misfolded and also folded substrates, some of which are involved in cell division and survival of cellular stress. The N-terminal domain of Lon facilitates substrate recognition, but how the domains confer such activity has remained unclear. Here, we report the full-length structure of Lon protease from Thermus thermophilus at 3.9 A resolution in a substrate-engaged state. The six N-terminal domains are arranged in three p...
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#1Junyan Duan (UCI: University of California, Irvine)
#2Elyse N. Greenberg (UCI: University of California, Irvine)H-Index: 3
Last. Bogi AndersenH-Index: 38
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Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light-dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the ...
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#1Yixun Lu (Chinese PLA General Hospital)H-Index: 3
#2Kai Li (Chinese PLA General Hospital)
Last. Lin Chen (Chinese PLA General Hospital)H-Index: 32
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Gastric cancer (GC) has a dismal prognosis and is also one of the most commonly diagnosed malignancies worldwide. circRNAs are covalently closed circular RNA molecules without 5'-cap and a 3'-tail, currently listed among the broad noncoding RNA family. circRNAs participate in a variety of pathophysiological processes relevant to human diseases, especially malignancies, including GC. Compelling evidence has shown that circRNAs can function by sponging miRNAs, interacting with RNA binding proteins...
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#1Kamel Chibani (University of Essex)
#2Boas Pucker (University of Cambridge)H-Index: 10
Last. Amanda P. Cavanagh (University of Essex)H-Index: 8
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Thioredoxins (TRXs), a large subclass of ubiquitous oxidoreductases, are involved in thiol redox regulation. Here, we performed a comprehensive analysis of TRXs in the Arabidopsis thaliana genome, revealing 41 genes encoding 18 typical and 23 atypical TRXs, and 6 genes encoding thioredoxin reductases (TRs). The high number of atypical TRXs indicates special functions in plants that mostly await elucidation. We identified an atypical class of thioredoxins called TRX-c in the genomes of photosynth...
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#1Caroline Molinaro (university of lille)H-Index: 1
#2Alain Martoriati (university of lille)H-Index: 9
Last. Katia Cailliau (university of lille)H-Index: 20
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The high-affinity tyrosine kinase receptor MET plays a pivotal role in several facets of cell regulation. Although its mitogenic effect is well documented, some aspects of connection patterns between signaling pathways involved in cell cycle progression remain to be deciphered. We have used a tractable heterologous expression system, the Xenopus oocyte, to detect connections between distinct MET signaling cascades involved in G2/M progression. Our results reveal that Src acts as an adapter via i...
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#1Julia Peukes (LMB: Laboratory of Molecular Biology)H-Index: 3
#2Xiaoli Xiong (LMB: Laboratory of Molecular Biology)H-Index: 18
Last. John A. G. Briggs (LMB: Laboratory of Molecular Biology)
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Influenza A virus matrix protein 1 (M1) is the most abundant protein within virions and functions at multiple steps of the virus life cycle, including nuclear RNA export, virus particle assembly, and virus disassembly. Two recent publications have presented the first structures of full-length M1 and show that it assembles filaments in vitro via an interface between the N- and C-terminal domains of adjacent monomers. These filaments were found to be similar to those that form the endoskeleton of ...
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