miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition.

Published on Feb 4, 2019in Journal of Experimental & Clinical Cancer Research7.068
· DOI :10.1186/S13046-019-1060-Z
Rihan El Bezawy3
Estimated H-index: 3
Stella Tinelli22
Estimated H-index: 22
+ 8 AuthorsNadia Zaffaroni66
Estimated H-index: 66
Background Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a considerable fraction of patients still experience relapse due to the development of resistance. Radioresistance is a complex and still poorly understood phenomenon involving the deregulation of a variety of signaling pathways as a consequence of several genetic and epigenetic abnormalities. In this context, cumulative evidence supports a functional role of microRNAs in affecting radioresistance, suggesting the modulation of their expression as a novel radiosensitizing approach. Here, we investigated for the first time the ability of miR-205 to enhance the radiation response of PCa models.
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