Journal of Experimental & Clinical Cancer Research
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7.07
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3483
Papers 3860
1 page of 386 pages (3,860 results)
Newest
#1Yixin TanH-Index: 9
#2Quanzhu Chen (MOE: Chinese Ministry of Education)H-Index: 1
Last. Mei Yi (MOE: Chinese Ministry of Education)H-Index: 17
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#1Gang Chen (First Affiliated Hospital of Wenzhou Medical University)H-Index: 5
#2Yi Wang (WMU: Wenzhou Medical College)H-Index: 59
Last. Zhen Yang (SDU: Shandong University)H-Index: 1
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Background null Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that the POSTN gene is closely related to the malignant progression and poor prognosis of HCC. This study aimed to elucidate the role of POSTN in generating LCSCs and maintaining their stemness as well as the underlying mechanisms. null Methods null Human HCC tissues and matched adjacent normal tissues were o...
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#1Pablo Hernández-Camarero (University of Jaén)H-Index: 2
#2Elena López-Ruiz (UGR: University of Granada)H-Index: 12
Last. Macarena Perán (UGR: University of Granada)H-Index: 17
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It has been well documented that the tumor microenvironment (TME) plays a key role in the promotion of drug resistance, the support of tumor progression, invasiveness, metastasis, and even the maintenance of a cancer stem-like phenotype. Here, we reviewed TME formation presenting it as a reflection of a tumor’s own organization during the different stages of tumor development. Interestingly, functionally different groups of stromal cells seem to have specific spatial distributions within the TME...
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#1Marius Kemper (UHH: University of Hamburg)H-Index: 2
#2Alina Schiecke (UHH: University of Hamburg)
Last. Kristoffer Riecken (UHH: University of Hamburg)H-Index: 22
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Background null Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models. In the absence of selectins in the host, the integrin subunit alpha-V (ITGAV, CD51) was upregulated in the remaining metastatic deposits. Here we present the first experimental study to investigate if ITGAV plays a functional role in PDA tumor growth and progression with a particular focus on intraperitoneal carcinomatosis. null Meth...
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#1Yasutoshi Fujii (Hiroshima University)
#2Atsushi Ono (Hiroshima University)H-Index: 15
Last. Takashi Nakahara (Hiroshima University)H-Index: 19
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Background null There has been a recent surge in interest in predicting biological effects associated with genomic alterations in order to implement personalized cancer treatment strategies. However, no reports have yet evaluated the utility of profiling blood-based circulating tumor DNA (ctDNA) in hepatocellular carcinoma (HCC) patients treated with lenvatinib (LEN). null Method null We retrospectively performed ctDNA next-generation sequencing (NGS) analysis in 24 patients with advanced HCC at...
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#1Peixin Dong (Hokkaido University)H-Index: 26
#2Ying Xiong (SYSU: Sun Yat-sen University)H-Index: 17
Last. Hidemichi Watari (Hokkaido University)H-Index: 35
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Background null Epithelial-to-mesenchymal transition (EMT) and aerobic glycolysis are fundamental processes implicated in cancer metastasis. Although increasing evidence demonstrates an association between EMT induction and enhanced aerobic glycolysis in human cancer, the mechanisms linking these two conditions in endometrial cancer (EC) cells remain poorly defined. null Methods null We characterized the role and molecular mechanism of the glycolytic enzyme hexokinase 2 (HK2) in mediating EMT an...
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#1Jorrit De Waele (University of Antwerp)H-Index: 10
#2Tias Verhezen (University of Antwerp)
Last. Evelien Smits (University of Antwerp)H-Index: 36
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Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to develop durable immunity with memory will be key. Polyinosinic:polycytidylic acid, or poly(I:C), and its derivative poly-ICLC could serve as a priming or boosting therapy to unleash lymphocytes and other factors in the (immuno)therapeutic armory against gliobla...
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#1Yali Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Kun Zheng (HUST: Huazhong University of Science and Technology)
Last. Yanmei Zou (HUST: Huazhong University of Science and Technology)
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Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP) plays a central role in many cellular processes, including DNA repair, replication, and transcription. PARP induces the occurrence of poly (ADP-ribosylation) (PARylation) when DNA single strand breaks (SSB) ...
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#1Kosuke Sasaki (Chiba University)H-Index: 1
#2Shigetsugu Takano (Chiba University)H-Index: 24
Last. Masayuki Ohtsuka (Chiba University)H-Index: 42
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Background null Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ductal adenocarcinoma (PDAC). However, its mechanism of action remains unclear. Here, we elucidated the functional roles of C4BPA in PDAC cells and the tumor microenvironment. null Methods null We assessed stromal C4BPA, the C4BPA binding partner CD40...
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#1Shumei Song (University of Texas MD Anderson Cancer Center)H-Index: 22
#2Yan Xu (PRC: China Medical University (PRC))H-Index: 6
Last. Yibo Fan (University of Texas MD Anderson Cancer Center)H-Index: 1
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Background null Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and metastatic models to study molecular mechanisms of PC and for preclinical screening of new therapies. null Methods null PC cell lines were developed from patient-derived PC cells. The tumorigenicity and metastatic potential were investigated by subcutaneously (PDXs) and orthoto...
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