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Original paper

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells

Volume: 23, Issue: 4, Pages: 2890 - 2900
Published: Feb 1, 2019
Abstract
Both type 2 diabetes (T2D) and obesity are characterized by excessive hyperlipidaemia and subsequent lipid droplet (LD) accumulation in adipose tissue. To investigate whether LDs also accumulate in β‐cells of T2D patients, we assessed the expression of PLIN2, a LD‐associated protein, in non‐diabetic (ND) and T2D pancreata. We observed an up‐regulation of PLIN2 mRNA and protein in β‐cells of T2D patients, along with significant changes in the...
Paper Details
Title
Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells
Published Date
Feb 1, 2019
Volume
23
Issue
4
Pages
2890 - 2900
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