Journal of Cellular and Molecular Medicine
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4.49
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5334
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1 page of 650 pages (6,500 results)
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#1Guanzheng Liu (Xuzhou Medical College)H-Index: 4
#2Huan Li (Xuzhou Medical College)H-Index: 4
Last. Rutong Yu (Xuzhou Medical College)H-Index: 12
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Glioblastoma multiforme (GBM), a fatal brain tumour with no available targeted therapies, has a poor prognosis. At present, radiotherapy is one of the main methods to treat glioma, but it leads to an obvious increase in inflammatory factors in the tumour microenvironment, especially IL-6 and CXCL1, which plays a role in tumour to resistance radiotherapy and tumorigenesis. Casein kinase 1 alpha 1 (CK1α) (encoded on chromosome 5q by Csnk1a1) is considered an attractive target for Tp53 wild-type ac...
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#1Yao-Ching Fang (TMU: Taipei Medical University)H-Index: 1
#2Jia-Yu Hsieh (TMU: Taipei Medical University)
Last. Yong Kwang Tu (TMU: Taipei Medical University)H-Index: 2
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We previously showed a hydroxamic acid-based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen-glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions. Intriguingly, the protective effect of this HDACi is via H3K14 or H4K5 acetylation-mediated differential BDNF isoform activation. BDNF is involved in cell proliferation and differentiation ...
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#1Jian Liu (Hunan University)H-Index: 3
#2Lin Liu (Hunan University)H-Index: 2
Last. Yu-Hong Wang (Hunan University)H-Index: 5
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Diabetes-related depression (DD) is a major complication of diabetes mellitus. Our previous studies indicated that glutamate (Glu) and hippocampal neuron apoptosis are key signal and direct factor leading to diabetes-related depression, respectively. However, the accurate pathogenesis remains to be unclear. We hypothesized that diabetes-related depression might be associated with the mitophagy-mediated hippocampal neuron apoptosis, triggered by aberrant Glu-glutamate receptor2 (GluR2)-Parkin pat...
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#1Min Hee Kim (IUPUI: Indiana University – Purdue University Indianapolis)
#2Steven D Green (IU: Indiana University)
Last. Heiko Konig (IU: Indiana University)H-Index: 15
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Major advances in the field of genomic technologies have led to an improvement in cancer diagnosis, classification and prognostication. However, many cancers remain incurable due to the development of drug resistance, minimal residual disease (MRD) and disease relapse, highlighting an incomplete understanding of the mechanisms underlying these processes. In recent years, the impact of non-genetic factors on neoplastic transformations has increasingly been acknowledged, and growing evidence sugge...
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#1Xiaopeng Song (NEAU: Northeast Agricultural University)H-Index: 6
#2Hui Bai (NEAU: Northeast Agricultural University)H-Index: 5
Last. Li Gao (NEAU: Northeast Agricultural University)H-Index: 9
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Endogenous homeostasis and peripheral tissue metabolism are disrupted by irregular fluctuations in activation, movement, feeding and temperature, which can accelerate negative biological processes and lead to immune reactions, such as rheumatoid arthritis (RA) and osteoarthritis (OA). This review summarizes abnormal phenotypes in articular joint components such as cartilage, bone and the synovium, attributed to the deletion or overexpression of clock genes in cartilage or chondrocytes. Understan...
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#1Liwei Wu (Fudan University)H-Index: 1
Last. Lin Wang (Fudan University)H-Index: 1
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Pulmonary tuberculosis (PTB) is a major global public health problem. The purpose of this study was to find biomarkers that can be used to diagnose tuberculosis. We used four NCBI GEO data sets to conduct analysis. Among the four data sets, GSE139825 is lung tissue microarray, and GSE83456, GSE19491 and GSE50834 are blood microarray. The differential genes of GSE139825 and GSE83456 were 68 and 226, and intersection genes were 11. Gene ontology (GO) analyses of 11 intersection genes revealed that...
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#1Hongchuang Ma (JNU: Jinan University)
#2Xiang Li (Beihua University)
Last. Hongzhi Li (Beihua University)
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IgA nephropathy (IgAN), the most common form of primary glomerulonephritis, is caused by immune system dysfunction and affects only the kidneys. miRNA was involved in IgAN, in which their roles are still unknown. Herein, we found increased glomerular medulla size, proteinuria, kidney artery resistance, kidney fibrosis and immune complex deposition in 5-month miR-25/93/106b cluster knockout (miR-TKO) mice. In vitro, the inhibition of miR-25 cluster could promote cell proliferation and increase fi...
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#1Yuanyuan Lin (Boston Children's Hospital)
Last. An Xie (NCU: Nanchang University)
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Acute myeloid leukaemia (AML) is a common hematopoietic disease that is harmful to the lives of children and adults. CircRNAs are aberrantly expressed in the haematologic malignancy cells. However, the expression of circTASP1 and its function in AML remain unclear. In this study, we showed that circTASP1 was significantly up-regulated in AML peripheral blood samples and cells. Knockdown of circTASP1 inhibited proliferation and promoted apoptosis of HL60 and THP-1 cells in vitro. Bioinformatics p...
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#1Jie Shi (SDU: Shandong University)
#2Shaoyi Wang (SDU: Shandong University)H-Index: 1
Last. Lei Cheng (SDU: Shandong University)H-Index: 15
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The mechanism of intervertebral disc degeneration is still unclear, and there are no effective therapeutic strategies for treating this condition. miRNAs are naturally occurring macromolecules in the human body and have many biological functions. Therefore, we hope to elucidate whether miRNAs are associated with intervertebral disc degeneration and the underlying mechanisms involved. In our study, differentially expressed miRNAs were predicted by the GEO database and then confirmed by qPCR and i...
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#1Dianhong Zhang (Zhengzhou University)H-Index: 6
#2Cui Liang (Zhengzhou University)H-Index: 8
Last. Yanzhou Zhang (Zhengzhou University)H-Index: 2
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Cardiac hypertrophy and the resultant heart failure are among the most common causes of morbidity and mortality worldwide; thus, identifying the key factor mediating pathological cardiac hypertrophy is critically important for developing the strategy to protect against heart failure. Runx1 (Runt-related transcription factor 1) acts as an essential transcription factor that functions in a variety of cellular processes including differentiation, proliferation, tissue growth and DNA damage response...
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