Journal of Cellular and Molecular Medicine
Papers 6,810
1 page of 681 pages (6,810 results)
Simvastatin serves as an effective therapeutic potential in the treatment of dental disease via alternating proliferation of dental pulp stem cells. First, western-blot and real-time quantitative PCR were used to detect the effect of simvastatin or LY294002 on the expression levels of AKT, miR-9 and KLF5, or determine the effect of miR-9. Simvastatin, KLF5 and AKT significantly enhanced the proliferation of pulp stem cells, whilst this effect induced by simvastatin was suppressed by LY294002, AK...
#1Xiaohua Ma (Soochow University)
#2Meng Zhang (Soochow University)
Last. Zhigang Miao (Soochow University)
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βII spectrin (β2SP) is encoded by Sptbn1 and is involved in the regulation of various cell functions. β2SP contributes to the formation of the myelin sheath, which may be related to the mechanism of neuropathy caused by demyelination. As one of the main features of cerebral ischemia, demyelination plays a key role in the mechanism of cerebral ischemia injury. Here, we showed that β2SP levels were increased, and this molecule interacted with TET2 after ischemic injury. Furthermore, we found that ...
#1Farzaneh Darbeheshti (TUMS: Tehran University of Medical Sciences)H-Index: 3
#2Mojdeh Mahdiannasser (TUMS: Tehran University of Medical Sciences)H-Index: 3
Last. Yaser MansooriH-Index: 10
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The aggressive and highly metastatic nature of triple-negative breast cancer (TNBC) causes patients to suffer from the poor outcome. HIF-1 signalling pathway is a prominent pathway that contributes to angiogenesis and metastasis progression in tumours. On the contrary, the undeniable importance of circular RNAs (circRNAs) as multifunctional non-coding RNAs (ncRNAs) has been identified in breast cancer. These ncRNAs owing to their high stability and specificity have been becoming a hotspot in can...
#1Fangli Chen (IUPUI: Indiana University – Purdue University Indianapolis)
#2Emilia Licarete (IUPUI: Indiana University – Purdue University Indianapolis)
Last. Heiko Konig (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 15
view all 17 authors...
Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and survive in specialised, oxygen (O2 )-deprived niches of the bone marrow. Although several AML drug targets such as FLT3, IDH1/2 and CD33 have been established in recent years, survival rates remain unsatisfactory, which indicates that other, yet unrecognized, mechanisms influence t...
#1Xumin LiH-Index: 8
Last. Gang Wu (ACTA: Academic Center for Dentistry Amsterdam)H-Index: 26
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Oxidative stress (OS)-induced mitochondrial damage and the subsequent osteoblast dysfunction contributes to the initiation and progression of osteoporosis. Notoginsenoside R1 (NGR1), isolated from Panax notoginseng, has potent antioxidant effects and has been widely used in traditional Chinese medicine. This study aimed to investigate the protective property and mechanism of NGR1 on oxidative-damaged osteoblast. Osteoblastic MC3T3-E1 cells were pretreated with NGR1 24 h before hydrogen peroxide ...
#1Wenyan Liu (XJTU: Xi'an Jiaotong University)H-Index: 6
Last. Xinglong Zheng (XJTU: Xi'an Jiaotong University)H-Index: 7
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Extracellular cold-inducible RNA-binding protein (CIRP) is a proinflammatory mediator that aggravates ischaemia-reperfusion injury (IRI). Normothermic machine perfusion (NMP) could effectively alleviate the IRI of the liver, but the underlying mechanism remains to be explored. We show that human DCD livers secreted a large amount of CIRP during static cold storage (CS), which is released into the circulation after reperfusion. The expression of CIRP was related to postoperative IL-6 levels and l...
#1Qing Wang (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 1
#2En Ma (MOE: Ministry of Education of the People's Republic of China)
Last. Dan-ni Ren (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 2
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Myocardial infarction (MI) is one of the leading causes of death worldwide, and due to the widespread and irreversible damage caused, new therapeutic treatments are urgently needed in order to limit the degree of ischaemic damage following MI. Aberrant activation of Wnt/β-catenin signalling pathway often occurs during cardiovascular diseases including MI, which results in excess production of reactive oxygen species (ROS) and further promotes myocardial dysfunction. Huoxin pill (HXP) is a Tradit...
#1Bo Zhan (CMU: China Medical University)H-Index: 9
#2Zhe Zhang (CMU: China Medical University)H-Index: 14
Last. Yuan-jun Jiang (CMU: China Medical University)H-Index: 4
view all 7 authors...
Sigma-2 receptor/TMEM97 is overexpressed in many tumours, and sigma-2 receptor ligands are under investigation for cancer therapy. We intended to evaluate the effect of PB28 on renal cancer in proliferation, migration and invasion in vitro and in vivo. Invasive renal cancer cell lines treated with PB28 (or sigma-2 receptor antagonist 1) were subjected to cell proliferation, migration and invasion assays. The therapeutic effect of PB28 was performed on nude mice. Western blot for proteins in the ...
#1Ziyan Zhang (North China University of Science and Technology)
#2Xuemin Gao (North China University of Science and Technology)H-Index: 5
Last. Jie Yang (North China University of Science and Technology)
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Skin fibrosis, which is characterized by fibroblast proliferation and increased extracellular matrix, has no effective treatment. An increasing number of studies have shown that microRNAs (miRNAs/miRs) participate in the mechanism of skin fibrosis, such as in limited cutaneous systemic sclerosis and pathological scarring. The objective of the present study was to determine the role of miR-411-3p in bleomycin (BLM)-induced skin fibrosis and skin fibroblast transformation. Using Western blot analy...
#1Huaji Jiang (STU: Shantou University)
#2Jialiang Zhong (Sun Yat-sen University)
Last. Liping Wang (University of South Australia)H-Index: 18
view all 9 authors...
Osteoporosis is characterized by increased bone fragility, and the drugs used at present to treat osteoporosis can cause adverse reactions. Gentiopicroside (GEN), a class of natural compounds with numerous biological activities such as anti-resorptive properties and protective effects against bone loss. Therefore, the aim of this work was to explore the effect of GEN on bone mesenchymal stem cells (BMSCs) osteogenesis for a potential osteoporosis therapy. In vitro, BMSCs were exposed to GEN at d...
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