Polygenic hazard score, amyloid deposition and Alzheimer’s neurodegeneration
Abstract
Mounting evidence indicates that the polygenic basis of late-onset Alzheimer’s disease can be harnessed to identify individuals at greatest risk for cognitive decline. We have previously developed and validated a polygenic hazard score comprising of 31 single nucleotide polymorphisms for predicting Alzheimer’s disease dementia age of onset. In this study, we examined whether polygenic hazard scores are associated with: (i) regional tracer uptake...
Paper Details
Title
Polygenic hazard score, amyloid deposition and Alzheimer’s neurodegeneration
Published Date
Jan 24, 2019
Journal
Volume
142
Issue
2
Pages
460 - 470
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