Review paper
Itaconate: the poster child of metabolic reprogramming in macrophage function
Abstract
Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage activation. The main reason macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. A role for...
Paper Details
Title
Itaconate: the poster child of metabolic reprogramming in macrophage function
Published Date
Jan 31, 2019
Journal
Volume
19
Issue
5
Pages
273 - 281