Nature Reviews Immunology
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53.11
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3,868
Papers 3,781
1 page of 379 pages (3,781 results)
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This study links the complement-mediated retraction of T helper 1 cell responses to vitamin D receptor signalling, an autoregulatory loop that might be impaired in patients with COVID-19.
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#1Felix Richter (University of Oxford)H-Index: 13
#2Irina A. Udalova (University of Oxford)H-Index: 42
A preprint by Sanin et al. establishes a transcriptional framework to define common macrophage activation states across tissues and biological conditions.
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#1Gabrielle S. Lubitz (MSSM: Icahn School of Medicine at Mount Sinai)
#2Joshua Brody (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 27
A preprint by Kersten et al. describes a positive-feedback loop promoting the mutual formation of tumour-associated macrophages and exhausted T cells as they move towards the tumour core.
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B cell-derived GABA can inhibit T cell and macrophage activation and limit anti-tumour T immune responses.
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Transient skin inflammation in early life leads to the development of T helper 2 cell–fibroblast niches that alter wound repair responses and may drive fibrotic pathology later in life.
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#1Tatsuya Manabe (DZNE: German Center for Neurodegenerative Diseases)H-Index: 1
#2Michael T. Heneka (DZNE: German Center for Neurodegenerative Diseases)H-Index: 93
Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common but shows a dynamic trajectory over time. Half of all patients with sepsis develop SAE in the intensive care unit, and some survivors present with sustained cognitive impairments for several years after initial sepsis onset. It is not clear why some, but not all, patients develop SAE and also the factors that determine the ...
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#1Zivile Békássy (Lund University)H-Index: 10
#2Ingrid Lopatko Fagerström (Lund University)H-Index: 1
Last. Diana Karpman (Lund University)H-Index: 54
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During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in ...
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#1Joel BabdorH-Index: 1
#2Amy Fan (SU: Stanford University)H-Index: 3
Last. Elaine Kouame (UC: University of Chicago)H-Index: 1
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Black In Immuno harnesses social media and digital platforms to connect Black immunologists with one another and with the rest of the scientific ecosystem. We invite you to join us, to connect with and amplify Black immunologists, and to contribute to creating a more inclusive and innovative biomedical community.
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#1Thierry Huby (INSERM: Inserm)H-Index: 27
#2Emmanuel L. Gautier (INSERM: Inserm)H-Index: 32
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis (NASH), cirrhosis or even hepatocellular carcinoma. NAFLD is a major health burden, and its incidence is increasing worldwide. Although it is primarily a disease of disturbed metabolism, NAFLD involves several immune cell-mediated inflammatory processes, particularly when reaching the stage of NASH, at which point infla...
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