Nature Reviews Immunology
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#1Payel Roy (La Jolla Institute for Allergy and Immunology)H-Index: 5
#2Marco Orecchioni (La Jolla Institute for Allergy and Immunology)H-Index: 13
Last. Klaus Ley (La Jolla Institute for Allergy and Immunology)H-Index: 135
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Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in preclinical models and emerging evidence in humans have established the crucial roles of the innate and adaptive immune systems in driving atherosclerosis-associated chronic inflammation in arterial blood vessels. New techniques have highlighted the enormous heterogeneity of leukocyte subsets in the arterial wall that have pro-inflammatory or regulatory roles in atherogenesis. Understanding the homing and ac...
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#1Setu M Vora (Boston Children's Hospital)H-Index: 2
#2Judy Lieberman (Boston Children's Hospital)H-Index: 102
Last. Hao Wu (Boston Children's Hospital)H-Index: 108
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The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes. Severe disease is characterized by dysregulated cytokine release, pneumonia and acute lung injury, which can rapidly progress to acute respiratory distress syndrome, disseminated intravascular coagulation, multisystem failure and death. However, a mechanis...
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#1John S. Tregoning (Imperial College London)H-Index: 32
#2Katie E Flight (Imperial College London)H-Index: 1
Last. Benjamin F. Pierce (Imperial College London)H-Index: 1
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Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we provide a snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern. Where they have been deployed in a high proportion of the adult population, the currently approved va...
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The type 2 cytokine TSLP acts on T cells to promote sebum secretion and uses up lipids in this process, leading to loss of white adipose tissue.
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#1Ed C. Lavelle (Trinity College, Dublin)H-Index: 58
#2Ross W. Ward (Trinity College, Dublin)
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#1Ed C. Lavelle (Trinity College, Dublin)H-Index: 58
#2Ross W. Ward (Trinity College, Dublin)
Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. In principle, the induction of adaptive immunity at mucosal sites, involving secretory antibody responses and tissue-resident T cells, has the capacity to prevent an infection from becoming established in the first place, rather than only curtailing infection and protecting against the development of disease symptoms. Although numerous effective mucosal vaccines are ...
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Top fields of study
Innate immune system
Immunology
T cell
Medicine
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Immune system
Cell biology