The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
Abstract
MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically negligible. Here we describe a module of microRNAs, constituted by miR-124, miR-128 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in gliomagenesis. Each one of these miRs targets several transcriptional regulators, including the oncogenic chromatin...
Paper Details
Title
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
Published Date
Jan 25, 2019
Journal
Volume
10
Issue
1
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