Chaperone-mediated autophagy is involved in the execution of ferroptosis

Significance This study reveals a common regulatory mechanism mediated by HSP90 that is shared by necroptosis and ferroptosis, two necrotic cell death mechanisms that have previously had no known mechanistic connections. Furthermore, this study demonstrates the involvement of chaperone-mediated autophagy in the execution of ferroptosis. Given the role of HSP90 as an important chaperone involved in major human maladies ranging from...