Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck

Published on Jun 1, 2019in Head and Neck-journal for The Sciences and Specialties of The Head and Neck2.538
· DOI :10.1002/HED.25636
Aurora Mirabile7
Estimated H-index: 7
(University of Milan),
Rosalba Miceli63
Estimated H-index: 63
+ 7 AuthorsLisa Licitra67
Estimated H-index: 67
(University of Milan)
Source
Abstract
BACKGROUND: In clinical trials of recurrent and metastatic head and neck carcinoma, Argiris et al have identified prognostic factors for overall survival (OS) and progression-free survival (PFS), weight loss, Eastern Cooperative Oncology Group performance status (ECOG-PS), tumor primary site, tumor differentiation, prior radiotherapy, deriving a two-group prognostic classification. This study evaluates Argiris's classification in "field-practice" patients. METHODS: The main analysis included 327 cases; a secondary analysis excluded 31 patients with oropharyngeal carcinoma (OPC) p16-positive and/or human papilloma virus (HPV)-positive. OS and PFS curves were estimated with the Kaplan-Meier method; multivariable Cox analyses were also performed. RESULTS: In the full series, OS was significantly different in patients with 0-2 and ≥3 adverse features (median, 14 vs 10 months; P = .03). PFS was statistically different in the two groups (median, 7 vs 5 months; P = .02). At a multivariable analysis investigating additional prognostic features, site of relapse and disease-free interval were significant predictors of OS and PFS. CONCLUSION: The Argiris's model was confirmed in a "field-practice" population. Moreover, we found additional putative prognostic factors.
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#2Crawford Middleton (University of Strathclyde)
Last. Jenny MontgomeryH-Index: 5
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Abstract Persistent hoarseness, as a symptom of laryngeal cancer, is one of the most frequent referrals made in the "urgent suspicion of cancer" (USOC) category in Scotland. This is equivalent to the "2 week wait" category in England. The Scottish Referral Guidelines (SRG) make no exclusions on age of patients with hoarseness, unlike the NICE guidelines (1) which stipulate that referrals are only received for patients 45 years or older. Hoarseness as a presentation of laryngeal cancer is importa...
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