TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

Volume: 38, Issue: 17, Pages: 3185 - 3200
Published: Jan 9, 2019
Abstract
Transforming growth factor-β (TGF-β) is major inducer of epithelial-to-mesenchymal transition (EMT), which associates with cancer cell metastasis and resistance to chemotherapy and targeted drugs, through both transcriptional and non-transcriptional mechanisms. We previously reported that, in cancer cells, heightened mitogenic signaling allows TGF-β-activated Smad3 to interact with poly(RC) binding protein 1 (PCBP1) and together they regulate...
Paper Details
Title
TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance
Published Date
Jan 9, 2019
Journal
Volume
38
Issue
17
Pages
3185 - 3200
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