GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation
Abstract
Glycogen synthase kinase-3β (GSK3β) is a key regulator of cellular homeostasis. In neurons, GSK3β contributes to the control of neuronal transmission and plasticity, but its role in epilepsy remains to be defined.Biochemical and electrophysiological methods were used to assess the role of GSK3β in regulating neuronal transmission and epileptogenesis. GSK3β activity was increased genetically in GSK3β[S9A] mice. Its effects on neuronal...
Paper Details
Title
GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation
Published Date
Jan 1, 2019
Journal
Volume
39
Pages
377 - 387
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