Abstract null null Background null Assessment of the kinetics of SARS-CoV-2 antibodies is essential in predicting risk of reinfection and durability of vaccine protection. null null null Methods null This is a prospective, monocentric, longitudinal, cohort clinical study. Healthcare workers (HCW) from Strasbourg University Hospital were enrolled between April 6th and May 7th, 2020 and followed up to 422 days. Serial serum samples were tested for antibodies against the Receptor Binding Domain (RB...
#1Jared M. Andrews(WashU: Washington University in St. Louis)H-Index: 6
#2Sarah C. Pyfrom(WashU: Washington University in St. Louis)H-Index: 5
Last. Yi-Shan Lee(WashU: Washington University in St. Louis)H-Index: 6
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Abstract null Background null The most common B-cell cancers, chronic lymphocytic leukemia/lymphoma (CLL), follicular and diffuse large B-cell (FL, DLBCL) lymphomas, have distinct clinical courses, yet overlapping "cell-of-origin". Dynamic changes to the epigenome are essential regulators of B-cell differentiation. Therefore, we reasoned that these distinct cancers may be driven by shared mechanisms of disruption in transcriptional circuitry. null Methods null We compared purified malignant B-ce...
Abstract null null Background null The mycobiome is the fungal component of the gut microbiome and is implicated in several autoimmune diseases. However, its role in MS has not been studied. null null null Methods null In this case-control observational study, we performed ITS sequencing and characterised the gut mycobiome in people with MS (pwMS) and healthy controls at baseline and after six months. null null null Findings null The mycobiome had significantly higher alpha diversity and inter-s...
Last. Li Cao(Peking Union Medical College)H-Index: 12
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Abstract null null Background null Patients with breast cancer presenting with single lymph node metastasis (from a sentinel node) experience prolonged survival compared to patients with multiple lymph node metastases (≥3). However, little information is available on the genetic and immunological characteristics of breast cancer metastases within the regional lymph nodes as they progress from the sentinel lymph node (SLN) downstream to multiple regional lymph nodes (MLNs). null null null Methods...
Abstract null null Background null Biliary atresia (BA) is the most common obstructive cholangiopathy in neonates, often progressing to end-stage cirrhosis. BA pathogenesis is believed to be multifactorial, but the genetic contribution, especially for nonsyndromic BA (common form: > 85%) remains poorly defined. null null null Methods null We conducted whole exome sequencing on 89 nonsyndromic BA trios to identify rare variants contributing to BA etiology. Functional evaluation using patients’ li...
#1Elena M. Turek(NIH: National Institutes of Health)H-Index: 4
#2Michael J. Cox(NIH: National Institutes of Health)H-Index: 31
Last. Miriam F. Moffatt(NIH: National Institutes of Health)H-Index: 67
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Abstract null null Background null Normal airway microbial communities play a central role in respiratory health but are poorly characterized. Cigarette smoking is the dominant global environmental influence on lung function, and asthma has become the most prevalent chronic respiratory disease worldwide. Both conditions have major microbial components that are incompletely defined. null null null Methods null We investigated airway bacterial communities in a general population sample of 529 Aust...