Magnetic Resonance Texture Analysis in Identifying Complete Pathological Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer.

Published on Feb 1, 2019in Diseases of The Colon & Rectum3.991
· DOI :10.1097/DCR.0000000000001224
Medhat Aker2
Estimated H-index: 2
Balaji Ganeshan32
Estimated H-index: 32
(UCL: University College London)
+ 3 AuthorsTan Arulampalam12
Estimated H-index: 12
BACKGROUND:A certain proportion of patients with locally advanced rectal cancer experience complete response after undergoing neoadjuvant chemoradiotherapy. These patients might be suitable for a conservative “watch and wait” approach, avoiding high-morbidity surgery. Texture analysis is a new modal
📖 Papers frequently viewed together
1,039 Citations
2,480 Citations
305 Citations
#1Francesco Sclafani (The Royal Marsden NHS Foundation Trust)H-Index: 21
#2Gina Brown (The Royal Marsden NHS Foundation Trust)H-Index: 79
Last. Ian ChauH-Index: 71
view all 16 authors...
Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer
53 CitationsSource
#1Omer JalilH-Index: 2
#2Asim Afaq (UCL: University College London)H-Index: 14
Last. Tan ArulampalamH-Index: 12
view all 9 authors...
Aim The study aimed to investigate whether textural features of rectal cancer on magnetic resonance imaging (MRI) can predict long term survival in patients treated with long-course chemoradiotherapy. Method Textural analysis (TA) using a filtration-histogram technique of T2-weighted pre- and six-week post chemoradiotherapy MRI was undertaken using TexRAD, a proprietary software algorithm. Regions of interest enclosing the largest cross-sectional area of the tumour were manually delineated on th...
36 CitationsSource
#1Carlo N. De Cecco (MUSC: Medical University of South Carolina)H-Index: 36
#2Balaji GaneshanH-Index: 32
Last. Andrea LaghiH-Index: 63
view all 10 authors...
OBJECTIVE: The aim of this study was to determine whether texture features of rectal cancer on T2-weighted (T2w) magnetic resonance images can predict tumoral response in patients treated with neoadjuvant chemoradiotherapy (CRT). MATERIALS AND METHODS: We prospectively enrolled 15 consecutive patients (6 women, 63.2 ± 13.4 years) with rectal cancer, who underwent pretreatment and midtreatment 3-T magnetic resonance imaging. Treatment protocol consisted of neoadjuvant CRT with oxaliplatin and 5-f...
130 CitationsSource
#1D. A. M. SloothaakH-Index: 10
#2D. E. GeijsenH-Index: 1
Last. Pieter J. TanisH-Index: 58
view all 7 authors...
Neoadjuvant chemoradiotherapy (CRT) has been proven to increase local control in rectal cancer, but the optimal interval between CRT and surgery is still unclear. The purpose of this study was to analyse the influence of variations in clinical practice regarding timing of surgery on pathological response at a population level. All evaluable patients who underwent preoperative CRT for rectal cancer between 2009 and 2011 were selected from the Dutch Surgical Colorectal Audit. The interval between ...
183 CitationsSource
#1Francesca Ng (Mount Vernon Hospital)H-Index: 3
#2Balaji GaneshanH-Index: 32
Last. Vicky GohH-Index: 59
view all 5 authors...
Fine-texture features (lower entropy, kurtosis, and standard deviation; higher uniformity and skewness) were associated with a poorer 5-year overall survival rate in patients with colorectal cancer.
294 CitationsSource
#1Vicky GohH-Index: 59
#2Balaji GaneshanH-Index: 32
Last. Kenneth A. MilesH-Index: 56
view all 6 authors...
Purpose: To assess the changes in tumor CT texture following 2 cycles of TKIs; and to determine if tumor texture correlates with measured time to progression in metastatic renal cell cancer treated with TKIs. Materials and Methods: Institutional review board waiver was obtained for this retrospective analysis. Contrast enhanced CT texture parameters were assessed in 39 patients with metastatic renal cell cancer treated with a TKI. 87 metastases were analysed at baseline and following 2 cycles of...
270 CitationsSource
#1Uday B. Patel (The Royal Marsden NHS Foundation Trust)H-Index: 7
#2Fiona TaylorH-Index: 9
Last. Gina Brown (National Health Service)H-Index: 79
view all 15 authors...
Purpose To assess magnetic resonance imaging (MRI) and pathologic staging after neoadjuvant therapy for rectal cancer in a prospectively enrolled, multicenter study. Methods In a prospective cohort study, 111 patients who had rectal cancer treated by neoadjuvant therapy were assessed for response by MRI and pathology staging by T, N and circumferential resection margin (CRM) status. Tumor regression grade (TRG) was also assessed by MRI. Overall survival (OS) was estimated by using the Kaplan-Mei...
401 CitationsSource
#1Zhaohai Yang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 14
#1Zhaohai Yang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. David S. KlimstraH-Index: 145
view all 3 authors...
The Ki67 labeling index is known to correlate with survival in patients with neuroendocrine tumors (NETs). A grading scheme recently endorsed by the World Health Organization for gastroenteropancreatic NETs classifies well-differentiated NETs into 2 categories based on the Ki67 labeling index: low (
226 CitationsSource
#1Monique Maas (Maastricht University Medical Centre)H-Index: 34
#2Patty J. Nelemans (Maastricht University Medical Centre)H-Index: 50
Last. Geerard L. Beets (Maastricht University Medical Centre)H-Index: 70
view all 18 authors...
Summary Background Locally advanced rectal cancer is usually treated with preoperative chemoradiation. After chemoradiation and surgery, 15–27% of the patients have no residual viable tumour at pathological examination, a pathological complete response (pCR). This study established whether patients with pCR have better long-term outcome than do those without pCR. Methods In PubMed, Medline, and Embase we identified 27 articles, based on 17 different datasets, for long-term outcome of patients wi...
1,086 CitationsSource
#1Marcus D. Ruopp (NIH: National Institutes of Health)H-Index: 5
#2Neil J. Perkins (NIH: National Institutes of Health)H-Index: 32
Last. Enrique F. Schisterman (NIH: National Institutes of Health)H-Index: 64
view all 4 authors...
The receiver operating characteristic (ROC) curve is used to evaluate a biomarker's ability for classifying disease status. The Youden Index (J), the maximum potential effectiveness of a biomarker, is a common summary measure of the ROC curve. In biomarker development, levels may be unquantifiable below a limit of detection (LOD) and missing from the overall dataset. Disregarding these observations may negatively bias the ROC curve and thus J. Several correction methods have been suggested for m...
498 CitationsSource
Cited By20
#1Arnaldo StanzioneH-Index: 11
#2Francesco VerdeH-Index: 21
Last. Simone MaureaH-Index: 23
view all 0 authors...
#2Lirong Song (PRC: China Medical University (PRC))H-Index: 3
view all 3 authors...
#1Yue-Yue Wang (Nanjing Medical University)
#2Qian Wu (Nanjing Medical University)H-Index: 2
Last. Huanhuan Chen (Nanjing Medical University)H-Index: 9
view all 9 authors...
PURPOSE To evaluate the value of magnetic resonance imaging (MRI)-based texture analysis of extraocular muscle (EOM) and orbital fat (OF) in monitoring and predicting the response to glucocorticoid (GC) therapy in patients with thyroid-associated ophthalmopathy (TAO). METHODS Thirty-seven active and moderate-to-severe TAO patients (responders, n=23; unresponders, n=14) were retrospectively enrolled. MRI-based texture parameters (entropy, uniformity, skewness and kurtosis) of EOM and OF were meas...
Complete tumor response can be achieved in a certain proportion of patients with locally advanced rectal cancer, who achieve maximal response to neoadjuvant therapy (NAT). For these patients, a watch-and-wait (WW) or nonsurgical strategy has been proposed and is becoming widely practiced in order to avoid unnecessary surgical complications. Therefore, a non-invasive, reliable diagnostic tool for accurately evaluating complete tumor response is needed. Magnetic resonance imaging (MRI) plays a cru...
#1Nina J Wesdorp (VU: VU University Amsterdam)H-Index: 3
#2Tessa Hellingman (VU: VU University Amsterdam)H-Index: 1
Last. Geert Kazemier (VU: VU University Amsterdam)H-Index: 63
view all 8 authors...
Advanced medical image analytics is increasingly used to predict clinical outcome in patients diagnosed with gastrointestinal tumors. This review provides an overview on the value of radiomics in predicting response to treatment in patients with gastrointestinal tumors. A systematic review was conducted, according to PRISMA guidelines. The protocol was prospectively registered (PROSPERO: CRD42019128408). PubMed, Embase, and Cochrane databases were searched. Original studies reporting on the valu...
4 CitationsSource
#1Sajad P. ShayestehH-Index: 4
#2Mostafa Nazari (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 4
Last. Habib ZaidiH-Index: 66
view all 12 authors...
Objectives We evaluate the feasibility of treatment response prediction using MRI-based pre-, post- and delta-radiomic features for locally advanced rectal cancer (LARC) patients treated by neoadjuvant chemoradiation therapy (nCRT). Materials and methods This retrospective study included 53 LARC patients divided into a training set (Center#1, n=36) and external validation set (Center#2, n=17). T2-weighted (T2W) MRI were acquired for all patients, 2 weeks before and 4 weeks after nCRT. Ninety-six...
1 CitationsSource
#1Ryota Nakanishi (Kyushu University)H-Index: 15
#2Eiji Oki (Kyushu University)H-Index: 57
Last. Masaki Mori (Kyushu University)H-Index: 131
view all 18 authors...
OBJECTIVE The aim of this study was to develop a radiomics-based prediction model for the response of colorectal liver metastases to oxaliplatin-based chemotherapy. METHODS Forty-two consecutive patients treated with oxaliplatin-based first-line chemotherapy for colorectal liver metastasis at our institution from August 2013 to October 2019 were enrolled in this retrospective study. Overall, 126 liver metastases were chronologically divided into the training (n = 94) and validation (n = 32) coho...
2 CitationsSource
#1Lirong Song (PRC: China Medical University (PRC))H-Index: 3
#1Nazlı Pınar Karahan Şen (Dokuz Eylül University)H-Index: 1
#2Ayşegül Aksu (Dokuz Eylül University)H-Index: 1
Last. Gamze Çapa Kaya (Dokuz Eylül University)H-Index: 8
view all 3 authors...
OBJECTIVE The aim of this study was to assess the value of baseline 18F-FDG PET/CT in predicting the response to neoadjuvant chemo-radiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) via the volumetric and texture data obtained from 18F-FDG PET/CT images. METHODS In total, 110 patients who had undergone NCRT after initial PET/CT and followed by surgical resection were included in this study. Patients were divided into two groups randomly as a train set (n: 88) and test set...
1 CitationsSource
#1H C Lu (Northeastern University (China))
#1Hecheng Lu (NU: Northeastern University)H-Index: 3
Last. Jiandong Yin (PRC: China Medical University (PRC))H-Index: 2
view all 3 authors...
Background: Accurate evaluation of local invasion (T-stage) of rectal cancer is essential for treatment planning. A search of PubMed database indicated that the correlation between texture features from T2-weighted magnetic resonance imaging (T2WI) (MRI) and T-stage has not been explored extensively. Purpose: To evaluate the performance of texture analysis using sagittal fat-suppression combined with transverse T2WI for determining T-stage of rectal cancer. Methods: One hundred and seventy-four ...