Original paper

Applying multivariate methods in the estimation of bioactivity properties of acetamide derivatives

Volume: 31, Issue: 6, Pages: 497 - 504
Published: Dec 1, 2018
Abstract
It has been established that the selected acetamide derivatives fulfill Veber’s and Pardridge’s rule of good bioavailability. The lipophilicity as a crucial molecular descriptor of biological activity for acetamide derivatives was determined by reversed-phase thinlayer chromatography (RP-TLC) in different mixtures of water and organic modifiers (ethanol and tetrahydrofuran). Also, lipophilicity was examined mathematically, by using relevant...
Paper Details
Title
Applying multivariate methods in the estimation of bioactivity properties of acetamide derivatives
Published Date
Dec 1, 2018
Volume
31
Issue
6
Pages
497 - 504
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