Gyöngyi Vastag
University of Novi Sad
Computational chemistryChemometricsIonic liquidMultivariate statisticsMolecular descriptorOrganic chemistryInorganic chemistryChemistryPartition coefficientMaterials scienceLipophilicityCorrosionPrincipal component analysisAcetonitrileSubstituentSolventStandard measureErosion corrosion of copper water tubesMoleculeChromatographyLinear regressionCopper
32Publications
6H-index
123Citations
Publications 31
Newest
#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi Vastag (University of Novi Sad)H-Index: 6
Preliminary assessment of the bioactive profile of azo derivatives was performed applying drug-likeness rules. As the presumed criteria of lipophilicity chromatographic parameters ( R M 0 , m and C 0 ) were calculated in mixtures water/ methanol and water/ acetonitrile by using reversed phase thin-layer chromatography (RPTLC C18/ UV254s). The relationships between chromatographic parameters and relevant software parameters of biological activity of azo derivatives were examined by linear regress...
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Derivatives of thiocarbohydrazone studied so far have shown great biological activity such as antioxidant, antimicrobial, and anticancer. Most of these compounds are bis-substituted derivatives, while monothiocarbohydrazones are much less investigated. Еighteen monothiocarbohydrazones were synthesized and subjected to physicochemical characterization in order to facilitate the examination of their potential biological activity and application in future studies. The structure of synthesized deriv...
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#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Dušan Mijin (University of Belgrade)H-Index: 22
Last. Gyöngyi Vastag (University of Novi Sad)H-Index: 6
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The selected diphenylacetamide derivatives were subjected to chromatographic and in silico approach in order to obtain significant information about their structure-activity relationships. As an ea...
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#1Gorana Mrdjan (University of Novi Sad)H-Index: 1
#2Borko Matijević (University of Novi Sad)H-Index: 6
Last. Ivana Stojiljković (University of Belgrade)H-Index: 2
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Carbohydrazones are compounds that are increasingly studied due to their wide potential biological activity. Monocarbohydrazones (mCHs), as one of the carbohydrazone derivatives, so far have been poorly investigated. For a more detailed study, in this paper, eighteen compounds of monocarbohydrazones (eight known and ten newly synthesized derivatives) were synthesized and characterized using NMR and IR spectroscopy. As carbohydrazones show E/Z isomerization caused by the presence of the imino gro...
1 CitationsSource
#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi VastagH-Index: 6
Last. Aleksandar D. MarinkovićH-Index: 21
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Biological activity of a molecule is closely related to its lipophilicity. This significant parameter was determinedfor a group of potentially bioactive N-(4-phenylmonosubstituted)-2-cyanoacetamides applying thin-layer chromatography on reversed phase (RP-TLC) in mixtures of water and two organic modifiers separately, i-propanol and dioxane. The effect of the chemical structure of derivatives and the influence of the applied organic modifier on their retention were studied. The determined chroma...
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#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi Vastag (University of Novi Sad)H-Index: 6
Last. Ivana Stojiljković (University of Belgrade)H-Index: 2
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AbstractBarbiturate derivatives were evaluated for their parameters of biological activity by applying linear regression and two multivariate methods (Cluster analysis and Principal component analysis). The lipophilicity of the studied barbiturates was determined on the modified carriers C18 in mixtures of water and four organic modifiers separately (methanol, n-propanol, acetone and tetrahydrofuran) by performing reversed phase thin layer chromatography and by applying relevant software package...
3 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Biljana Kaurinovic (University of Novi Sad)H-Index: 12
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1 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Ljubica Grbović (University of Novi Sad)H-Index: 5
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It has been established that the selected acetamide derivatives fulfill Veber’s and Pardridge’s rule of good bioavailability. The lipophilicity as a crucial molecular descriptor of biological activity for acetamide derivatives was determined by reversed-phase thinlayer chromatography (RP-TLC) in different mixtures of water and organic modifiers (ethanol and tetrahydrofuran). Also, lipophilicity was examined mathematically, by using relevant software packages. The effects of the substituent on th...
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#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Abdul Shaban (MTA: Hungarian Academy of Sciences)H-Index: 6
Last. Slobodan Gadžurić (University of Novi Sad)H-Index: 16
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Abstract 1-butyl-3-ethylimidazolium bromide ionic liquid, [beim]Br, was studied experimentally and theoretically as a potential inhibitor of copper corrosion in acidic media (pH = 3) by dc polarization, quartz crystal microbalance (QCM), scanning electron microscopy (SEM) and density functional theory (DFT). This ionic liquid is selected to study an effect of the alkyl chain length at the position N-3, since so far only ionic liquids with different alkyl substituents at the position N-1 are inve...
22 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Fathi H. AssalehH-Index: 5
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Abstract Lipophilicity as key molecular descriptor of potential biological activity for selected derivatives of azo dyes was determined mathematically, by using relevant software packages and by reversed-phase thin-layer chromatography (RPTLC) on C18 and cyano modified carriers in mixtures of water/n-propanol and water/acetone. The obtained chromatographic parameters, RM0 and m, of the examined azo dyes were correlated with the standard measure of lipophilicity, log P, important pharmacokinetic ...
1 CitationsSource