Suzana Apostolov
University of Novi Sad
Biological activityAbsorption spectroscopySolvent effectsComputational chemistrySolvationChemometricsMultivariate statisticsMolecular descriptorChemical structureOrganic chemistryChemistryPartition coefficientLipophilicityPrincipal component analysisAcetonitrileSubstituentSolventStandard measureMoleculeChromatographyLinear regressionSolvatochromism
31Publications
5H-index
75Citations
Publications 30
Newest
#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi Vastag (University of Novi Sad)H-Index: 6
Preliminary assessment of the bioactive profile of azo derivatives was performed applying drug-likeness rules. As the presumed criteria of lipophilicity chromatographic parameters ( R M 0 , m and C 0 ) were calculated in mixtures water/ methanol and water/ acetonitrile by using reversed phase thin-layer chromatography (RPTLC C18/ UV254s). The relationships between chromatographic parameters and relevant software parameters of biological activity of azo derivatives were examined by linear regress...
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#2Borko MatijevićH-Index: 6
Last. Suzana ApostolovH-Index: 5
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#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Dušan Mijin (University of Belgrade)H-Index: 22
Last. Gyöngyi Vastag (University of Novi Sad)H-Index: 6
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The selected diphenylacetamide derivatives were subjected to chromatographic and in silico approach in order to obtain significant information about their structure-activity relationships. As an ea...
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#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi VastagH-Index: 6
Last. Aleksandar D. MarinkovićH-Index: 21
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Biological activity of a molecule is closely related to its lipophilicity. This significant parameter was determinedfor a group of potentially bioactive N-(4-phenylmonosubstituted)-2-cyanoacetamides applying thin-layer chromatography on reversed phase (RP-TLC) in mixtures of water and two organic modifiers separately, i-propanol and dioxane. The effect of the chemical structure of derivatives and the influence of the applied organic modifier on their retention were studied. The determined chroma...
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#1Suzana Apostolov (University of Novi Sad)H-Index: 5
#2Gyöngyi Vastag (University of Novi Sad)H-Index: 6
Last. Ivana Stojiljković (University of Belgrade)H-Index: 2
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AbstractBarbiturate derivatives were evaluated for their parameters of biological activity by applying linear regression and two multivariate methods (Cluster analysis and Principal component analysis). The lipophilicity of the studied barbiturates was determined on the modified carriers C18 in mixtures of water and four organic modifiers separately (methanol, n-propanol, acetone and tetrahydrofuran) by performing reversed phase thin layer chromatography and by applying relevant software package...
3 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Biljana Kaurinovic (University of Novi Sad)H-Index: 12
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1 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Ljubica Grbović (University of Novi Sad)H-Index: 5
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It has been established that the selected acetamide derivatives fulfill Veber’s and Pardridge’s rule of good bioavailability. The lipophilicity as a crucial molecular descriptor of biological activity for acetamide derivatives was determined by reversed-phase thinlayer chromatography (RP-TLC) in different mixtures of water and organic modifiers (ethanol and tetrahydrofuran). Also, lipophilicity was examined mathematically, by using relevant software packages. The effects of the substituent on th...
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#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Fathi H. AssalehH-Index: 5
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Abstract Lipophilicity as key molecular descriptor of potential biological activity for selected derivatives of azo dyes was determined mathematically, by using relevant software packages and by reversed-phase thin-layer chromatography (RPTLC) on C18 and cyano modified carriers in mixtures of water/n-propanol and water/acetone. The obtained chromatographic parameters, RM0 and m, of the examined azo dyes were correlated with the standard measure of lipophilicity, log P, important pharmacokinetic ...
1 CitationsSource
#1Gyöngyi Vastag (University of Novi Sad)H-Index: 6
#2Suzana Apostolov (University of Novi Sad)H-Index: 5
Last. Borko Matijević (University of Novi Sad)H-Index: 6
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: In this study, the existence of biological potential of selected N-(substituted phenyl)-2-chloroacetamides was examined none empirically, as was the possibility of applying simple experimental technique in predicting essential properties which affect the biological activity of the compounds. By applying the Lipinski and Ghose's rules, it has been revealed that the examined chloroacetamides fulfill the theoretical requirements for bioactive compounds. In addition, lipophilicity was determined b...
8 CitationsSource
#1Suzana ApostolovH-Index: 5
#2Đenđi VaštagH-Index: 3
Primenom pravila Lipinskog za odabrane derivate cijanoacetamida je teorijski ispitana mogucnost postojanja njihove bioloske aktivnosti. Lipofilnost proucavanih cijanoacetamida je određena primenom odgovarajucih softverskih paketa i tankoslojnom hromatografijom na obrnutim fazama (RP TLC18 F254s) u sistemima voda-t-butanol, voda-dimetilformamid i voda-dimetilsulfoksid. Dobijeni hromatografski parametri, RM0 i m su metodom linearne regresije korelisani sa podeonim koeficijentom, log P, kao standar...
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