A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis

Introduction Nonhuman primates may serve as excellent models of sporadic age‐associated brain β‐amyloid deposition and Alzheimer's disease pathologic changes. We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease. Methods Nine middle‐aged (mean = 11.2 years) and nine aged (mean = 21.7 years) female vervet/African green monkeys underwent cerebrospinal fluid...