Human equilibrative nucleoside transporter 1 (hENT1) expression correlates with gemcitabine uptake and cytotoxicity in mantle cell lymphoma (MCL)

2348 null Nucleoside transporters (NTs) might play a relevant role in the intracellular targeting of many nucleoside analogues used in anticancer therapy. Two gene families (SLC28 and SLC29) encode the two types of human NTs, Concentrative Nucleoside Transporter (CNT) and Equilibrative Nucleoside Transporter (ENT) proteins. We have previously described that chronic lymphocytic leukemia (CLL) cells express both SLC28- and SLC29-related mRNAs,...