Dolors Colomer
University of Barcelona
GeneInternal medicinePathologyOncologyMolecular biologyCytotoxic T cellChemistryApoptosisCyclin D1ImmunologyMantle cell lymphomaIGHV@Chronic lymphocytic leukemiaLeukemiaMyeloid leukemiaLymphomaMutationCancer researchGeneticsMedicineBiologyGastroenterology
375Publications
88H-index
21.2kCitations
Publications 373
Newest
#1Irene López-OrejaH-Index: 1
Last. Dolors Colomer (University of Barcelona)H-Index: 88
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Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel alterations have been described. Some of them impact on the prognosis and evolution of patients. The approval of BTK inhibitors, PI3K inhibitors and Bcl-2 inhibitors has drastically changed the treatment of patients with CLL. The effect of these new targeted therapies has been widely analyzed in TP53-mutated cases, but few data exist about the resp...
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#2Fabian ArenasH-Index: 2
Last. Dolors Colomer (University of Barcelona)H-Index: 88
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Chronic lymphocytic leukemia (CLL) is a lymphoid malignancy characterized by the proliferation and accumulation of mature CD5+ B cells in the peripheral blood (PB), bone marrow (BM) and lymphoid ti...
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#1David F. Moreno (University of Barcelona)H-Index: 6
#2Arturo Pereira (University of Barcelona)H-Index: 41
Last. Carlos Fernández de Larrea (University of Barcelona)H-Index: 24
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We analyzed 171 patients with asymptomatic IgM monoclonal gammopathies (64 with IgM monoclonal gammopathy of undetermined significance-MGUS and 107 with smoldering Waldenstrom macroglobulinemia - SWM) who had a bone marrow (BM) evaluation performed at diagnosis. Abnormal free-light chain ratio (53% vs. 31%) and MYD88 mutation prevalence (66% vs. 30%) were higher in patients with SWM. No other differences were found among groups. With a median follow-up of 4.3 years, 14 patients progressed to Wal...
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#1Laura Llaó-Cid (DKFZ: German Cancer Research Center)H-Index: 1
#2Philipp M. Roessner (DKFZ: German Cancer Research Center)H-Index: 6
Last. Martina Seiffert (DKFZ: German Cancer Research Center)H-Index: 25
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Genome-wide association studies identified a single-nucleotide polymorphism (SNP) affecting the transcription factor Eomesodermin (EOMES) associated with a significantly increased risk to develop chronic lymphocytic leukemia (CLL). Epigenetic analyses, RNA sequencing, and flow cytometry revealed that EOMES is not expressed in CLL cells, but in CD8+ T cells for which EOMES is a known master regulator. We thus hypothesized that the increased CLL risk associated with the EOMES SNP might be explaine...
1 CitationsSource
#1Juan G. ValeroH-Index: 8
#2Alba Matas-Céspedes (AstraZeneca)H-Index: 7
Last. Patricia Pérez-GalánH-Index: 16
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Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival with macrophages playing a controversial role. In the present study, using FL primary samples and HK follicular dendritic cells (FDC) to mimic the germinal center, together with mouse models, we have analyzed the three-way crosstalk of FL-FDC-macrophages and derived therapeutic opportunities. Ex vivo primary FL-FDC co-cultures (n = 19) and in vivo mouse co-xenografts demonstrated that FL-FDC crosstalk favo...
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#1Vivien SchäferH-Index: 5
#2Helen E. White (Salisbury NHS Foundation Trust)H-Index: 31
Last. Thomas ErnstH-Index: 46
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PURPOSE Approximately 1-2% of chronic myeloid leukemia (CML) patients harbor atypical BCR-ABL1 transcripts that cannot be monitored by real-time quantitative PCR (RT-qPCR) using standard methodologies. Within the European Treatment and Outcome Study (EUTOS) for CML we established and validated robust RT-qPCR methods for these patients. METHODS BCR-ABL1 transcripts were amplified and sequenced to characterize the underlying fusion. Residual disease monitoring was carried out by RT-qPCR with speci...
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: Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to October 2018, were studied. Molecular studies were performed for the detection of clonally rearranged immunoglobulin by polymerase chain reaction.In all, 91 patients were included...
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#1Philipp M. Roessner (DKFZ: German Cancer Research Center)H-Index: 6
#2Laura Llaó Cid (DKFZ: German Cancer Research Center)H-Index: 3
Last. Martina Seiffert (DKFZ: German Cancer Research Center)H-Index: 25
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The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in CD4+ T cells, which has been linked to immunosuppressive and cytotoxic activities. We detected cytotoxic, programmed cell death protein-1 (PD-1) and EOMES co-expressing CD4+ T cells in lymph nodes (LNs) of patients with chronic lymphocytic leukemia (CLL) or diffuse large B-cell lymphoma. Transcriptome and flow cytometry analyses revealed that EOMES does not only drive IL-10 expression, but rather controls a ...
1 CitationsSource
#1Roser Vilarrasa-Blasi (University of Barcelona)H-Index: 7
#2Paula Soler-VilaH-Index: 3
Last. José I. Martín-SuberoH-Index: 46
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To investigate the three-dimensional (3D) genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia and mantle cell lymphoma patients, here we integrate in situ Hi-C and nine additional omics layers. Beyond conventional active (A) and inactive (B) compartments, we uncover a highly-dynamic intermediate compartment enriched in poised and polycomb-repressed chromatin. During B cell development, 28% of the compartments ch...
2 CitationsSource
#1Marta Magaz (University of Barcelona)H-Index: 6
#2Alberto Alvarez-Larrán (University of Barcelona)H-Index: 33
Last. Juan Carlos García-Pagán (University of Barcelona)H-Index: 100
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BACKGROUND & AIMS Myeloproliferative neoplasms (MPN) are the most frequent cause of non-tumoral non-cirrhotic splanchnic vein thrombosis (NC-SVT). Diagnosis of MPN is based on blood cell count alterations, bone marrow histology and detection of specific gene mutations. Next generation sequencing (NGS) allows the simultaneous evaluation of multiple genes implicated in myeloid clonal pathology. The aim of this study was to evaluate the potential role of NGS in the etiology of NC-SVT. METHODS DNA s...
4 CitationsSource