Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial

There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis response signatures (SRSs) have been identified. SRS1 is relatively immunosuppressed, whereas SRS2 is relatively immunocompetent.We aimed to categorize patients based on SRS endotypes to determine if these profiles influenced response to either norepinephrine or...