Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial

Volume: 199, Issue: 8, Pages: 980 - 986
Published: Apr 15, 2019
Abstract
There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis response signatures (SRSs) have been identified. SRS1 is relatively immunosuppressed, whereas SRS2 is relatively immunocompetent.We aimed to categorize patients based on SRS endotypes to determine if these profiles influenced response to either norepinephrine or...
Paper Details
Title
Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial
Published Date
Apr 15, 2019
Volume
199
Issue
8
Pages
980 - 986
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