American Journal of Respiratory and Critical Care Medicine
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#1Ludovic Gerard (Cliniques Universitaires Saint-Luc)H-Index: 6
#2Marylène LecocqH-Index: 9
Last. Charles Pilette (Catholic University of Leuven)H-Index: 31
view all 10 authors...
RATIONALE Angiotensin-Converting Enzyme (ACE) 2, the entry receptor for severe acute respiratory syndrome-Coronavirus 2 (SARS-CoV2), is expressed in type 2 alveolar epithelial cells (AT2) that may play key roles in post-injury repair. Imbalance between ACE2 and ACE has also been hypothesized to contribute to lung injury. OBJECTIVES To characterize the expression and distribution of ACE2 and ACE and to compare AT2 versus endothelial cell expression in COVID-related or -unrelated ARDS and controls...
#1Ankit Parekh (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
#2Thomas Tolbert (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. David M. Rapoport (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 57
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RATIONALE Determining whether an individual has obstructive or central sleep apnea is fundamental to selecting the appropriate treatment. OBJECTIVES Here we derive an automated breath-by-breath probability of obstruction, as a surrogate of gold-standard upper airway resistance, using hallmarks of upper airway obstruction visible on clinical sleep studies. METHODS From 5 NPSG signals (airflow, thoracic and abdominal effort, oxygen saturation, and snore), 9 features were extracted and weighted to ...
#1Menonli AdjobimeyH-Index: 4
#2Marcel A. Behr (McGill University)H-Index: 73
Last. Dick Menzies (Montreal Chest Institute)H-Index: 87
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#1Tomoharu Suzuki (SHM: Society of Hospital Medicine)
Last. Shunsuke Taito (Hiroshima University)H-Index: 5
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#1Erik A. Jensen (Children's Hospital of Philadelphia)H-Index: 16
#2Robin K. Whyte (Dal: Dalhousie University)H-Index: 22
Last. Robin S. Roberts (McMaster University)H-Index: 109
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RATIONALE Bronchopulmonary dysplasia increases the risk of disability in extremely preterm infants. Although the pathophysiology remains uncertain, prior exposure to intermittent hypoxemia may play a role in this relationship. OBJECTIVE To determine the association between prolonged episodes of intermittent hypoxemia and severe bronchopulmonary dysplasia. METHODS Post-hoc analysis of extremely preterm infants in the Canadian Oxygen Trial who survived to 36 weeks postmenstrual age. Oxygen saturat...
#1Chiagozie O. Pickens (NU: Northwestern University)H-Index: 3
#2Catherine A Gao (NU: Northwestern University)H-Index: 4
Last. Jason Arnold (NU: Northwestern University)H-Index: 4
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Rationale: Current guidelines recommend patients with SARS-CoV-2 pneumonia receive empirical antibiotics for suspected bacterial superinfection based on weak evidence. Rates of ventilator-associate...
1 CitationsSource
#1Donald H. Shaffner (Johns Hopkins University)H-Index: 27
#2Clifton W. Callaway (University of Pittsburgh)H-Index: 88
Top fields of study
Respiratory disease
Intensive care
Diabetes mellitus