Phase I Trial of Stereotactic Body Radiation Therapy (SBRT) to Multiple Metastatic Sites: A NRG Oncology Study

SBRT to all metastases (mets) is hypothesized to improve survival for oligometastatic breast and other cancers. However, there is scant prospective evidence supporting SBRT safety when multiple mets are targeted. In NRG-BR001 we sought to establish the safety of SBRT dose schedules commonly used to treat a single met, in patients (pts) with 2-4 mets. Eligibility included pts with 3-4 mets or 2 mets within 5 cm amenable to SBRT from breast, lung,...