Development of emulgel formulation for vaginal candidiasis: Pharmaceutical characterization, in vitro and in vivo evaluation

The aim of the investigation was to develop nanoemulsion (NE) based emulgel of Mentha essential oil (MEO: potent antifungal property) to ensure enriched and extended therapeutic effectiveness against various species of Candida and vaginal candidiasis. NE was prepared and optimized using central composite design. pH-triggered crosslinking of NE in carbopol 940 matrix (emulgel) was achieved by triethanolamine. Emulgel was evaluated for in vitro...