Early Diffusion Imaging Biomarkers of Prefrontal Lobe White Matter Microstructural Damage are Associated with Executive Dysfunction Following Radiation Therapy in Patients with Primary Brain Tumors: A Prospective, Longitudinal Study

White matter in the prefrontal area, namely the anterior cingulate (AC), is critical to executive functioning (EF): a cognitive domain important for occupational status and quality of life in patients with brain tumors. Using advanced imaging and serial cognitive testing, we evaluated the longitudinal effects of radiation therapy (RT) on prefrontal white matter microstructure and executive function (EF) in a prospective, longitudinal trial of...