Chikungunya, enfermedad emergente en América Latina. Descripción de los primeros casos en Chile.

Published on Sep 17, 2018in Revista Chilena De Infectologia0.52
· DOI :10.4067/S0716-10182018000400413
Cecilia Perret11
Estimated H-index: 11
(UC: Pontifical Catholic University of Chile),
Cecilia Vizcaya2
Estimated H-index: 2
(UC: Pontifical Catholic University of Chile)
+ 3 AuthorsConstanza Martínez12
Estimated H-index: 12
(UC: Pontifical Catholic University of Chile)
Sources
Abstract
Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and laboratory results. Results: 21 patients were enrolled and CHIK was confirmed in 16, who were further analyzed; 12 were female (75%), average age 39 years (27- 52). The Caribbean and South Americawere the most frequent sites of exposure. In 63%, the initial symptom was arthralgia. Most frequent symptoms were myalgias, malaise (both 100%), fever, and polyarthralgia (both 94%). The median duration of arthralgias was 90 days (3-262); in 53% arthralgias lasted ≥ 3 months. Main joints involved were ankles, hands, and wrists; 87% reported invalidating pain. Arthritis lasted longer in men than in women (p < 0.001). 38% of patients presented lymphopenia and one patient mild thrombocytopenia. Two patients required hospitalization, one with severe headaches, the other with acute pyelonephritis. Conclusions: Chikungunya should be suspected in returning travelers presenting with fever and severe polyarthralgia. Travelers to endemic areas should apply prevention measures to avoid mosquito bites.
References0
Newest
Cited By2
Newest
#1Marcela Sabino Cunha (UFRJ: Federal University of Rio de Janeiro)H-Index: 2
#2Pedro A G Costa (UFRJ: Federal University of Rio de Janeiro)H-Index: 1
Last. Luciana Jesus da Costa (UFRJ: Federal University of Rio de Janeiro)H-Index: 9
view all 9 authors...
Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) of epidemic concern, transmitted by Aedes ssp. mosquitoes, and is the etiologic agent of a febrile and incapacitating arthritogenic illness responsible for millions of human cases worldwide. After major outbreaks starting in 2004, CHIKV spread to subtropical areas and western hemisphere coming from sub-Saharan Africa, South East Asia, and the Indian subcontinent. Even though CHIKV disease is self-limiting and non-lethal, more than...
4 CitationsSource
#1Olga Vera-LastraH-Index: 22
#2Jesús Sepúlveda-Delgado (UNAM: National Autonomous University of Mexico)H-Index: 4
Last. Luis J. Jara (UNAM: National Autonomous University of Mexico)H-Index: 39
view all 6 authors...
Since 2004, the epidemic of alphavirus, mainly chikungunya viral (CHIKV) infection, has spread throughout the world and will continue to produce outbreaks due to viral mutations and the spread caused by travelers visiting endemic areas.
1 CitationsSource