Constanza Martínez
Pontifical Catholic University of Chile
Simulated body fluidInternal medicinePathologyPeriodontologyCellular differentiationCellMatrix (biology)ChemistryPediatricsExtracellular matrixMaterials scienceMesenchymal stem cellImmunologyMyofibroblastGrowth factorGranulation tissueSonic hedgehogInflammationArthritisPeriodontiumMethylglyoxalPlatelet-poor plasmaArthropathyMalaiseTravel medicinePeriodontal ligament stem cellsPlatelet-rich plasmaWound healingFibroblastAngiogenesisHeadachesChikungunyaStem cellPeriodontal diseasePeriodontal tissueCancer researchConnective tissueViability assayDiabetes mellitusBioinformaticsCell growthMedicineFibronectinBiologyPlateletCell biology
26Publications
12H-index
381Citations
Publications 26
Newest
#1Ignacio N. Retamal (University of Los Andes)H-Index: 6
#1Ignacio N Retamal (University of Los Andes)H-Index: 1
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 8 authors...
OBJECTIVES: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. MATERIAL AND METHODS: Type I diabetes was induced in rats through streptozotocin injection and periodontal wounds were performed. Wound healing was evaluated histologically at 2, 5, 7 and 15 days by measuring epithelial migration, neutrophil inf...
3 CitationsSource
#1Jassir Páez (Andrés Bello National University)H-Index: 1
#2Romina Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (Andrés Bello National University)H-Index: 1
view all 8 authors...
BACKGROUND AND OBJECTIVE: Aging is characterized by a decline in tissue structure and function that may be explained by the development of cellular senescence. However, the acquisition of specific phenotypic responses in senescent gingival fibroblasts is still poorly understood. Here, we have analyzed whether proliferation of primary cultures of human gingival fibroblasts may affect different cell functions relevant to cellular senescence and tissue deterioration. METHODS: Human gingival fibrobl...
4 CitationsSource
#1Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
#2Roberto S. Gómez (UC: Pontifical Catholic University of Chile)H-Index: 9
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 4 authors...
Objectives Cell-based therapies involve the need to expand cell cultures ex vivo for their subsequent implantation in an autologous manner. An important limitation regarding this technology is the use of fetal bovine serum (FBS) that has critical safety limitations. Platelet-derived fractions represent an autologous source of growth factors that may be used for the expansion of these cell cultures. Periodontal ligament (PDL) cells comprise a heterogeneous cell population that may not necessarily...
6 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
#2Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
Last. Christopher A. McCulloch (U of T: University of Toronto)H-Index: 86
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After injury to periodontal tissues a healing response is initiated that includes a series of sequential phases, which enable wound closure and partial restoration of tissue structure and function. Wound closure in periodontal tissues involves the tightly regulated coordination of resident cells in epithelial and connective tissue compartments. Multiple cell populations in these compartments synergize their metabolic activities to re-establish a mucosal seal that involves the underlying periodon...
35 CitationsSource
#1Cecilia PerretH-Index: 11
#2Cecilia VizcayaH-Index: 2
Last. Constanza MartínezH-Index: 12
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Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and l...
1 Citations
#1Cecilia Perret (UC: Pontifical Catholic University of Chile)H-Index: 11
#2Cecilia Vizcaya (UC: Pontifical Catholic University of Chile)H-Index: 2
Last. Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
view all 6 authors...
Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and l...
2 CitationsSource
#1L. Pavez (LMB: Laboratory of Molecular Biology)H-Index: 1
#2Nicolás Tobar (University of Chile)H-Index: 11
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 10 authors...
Background and Objectives An important goal of periodontal therapy is the modulation of the inflammatory response. To this end, several pharmacological agents have been evaluated. Triclosan corresponds to an antibacterial and anti-inflammatory agent currently used in periodontal therapy. Chitosan is a natural polymer that may act as a drug delivery agent and exerts antibacterial and anti-inflammatory activities. Therefore, an association between both molecules might be useful to prevent inflamma...
4 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
#2Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
Wound healing in mucosal tissues differs in many aspects from cutaneous wound healing, a unique aspect being the lack of scar formation. Oral mucosa wound healing comprises a series of sequential responses that allow the closure of ruptures in this tissue. This process is of critical importance to prevent the invasion of microorganisms or other agents into tissues avoiding the establishment of chronic inflammation. Since the oral mucosa is continually exposed to traumatic and infectious challeng...
Source
#1Ignacio N. Retamal (UC: Pontifical Catholic University of Chile)H-Index: 6
#2Romina Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 7 authors...
Background: Glucose-derived metabolites may alter the structure and biologic properties of important proteins in periodontium, such as collagens. As a consequence, it is possible that collagen-binding cells may change their phenotypic traits. Although the glucose-derived product methylglyoxal (MGO) has been detected in periodontal lesions, the precise effect of collagen glycation on gingival connective tissue biology is not fully understood. The present study evaluates whether collagen glycation...
4 CitationsSource
#1Ignacio N. Retamal (UC: Pontifical Catholic University of Chile)H-Index: 6
#2Ramón Faustino Díaz Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 10 authors...
Background and Objectives Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the effects of methylglyoxal on gingival cells are still poorly understood. In the present study, we have explored whether methylglyoxal or methylglyoxal-treated collagen may modulate cell viability, death and proliferation in gingival connective tis...
5 CitationsSource