Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial

Guidelines recommend the use of neuromodulators in patients with functional dyspepsia not responding to proton pump inhibitors (PPIs) and prokinetics; however, there is a lack of data from randomised controlled trials supporting their use. We aimed to assess the safety and efficacy of imipramine, a tricyclic antidepressant (TCA), in treatment-refractory functional dyspepsia.In this single-centre, double-blind, randomised controlled trial, we...