Biomedical engineering

Dentin

Soft tissue

Periodontal fiber

Tissue engineering

Scaffold

Cell biology

Dental alveolus

Biology

Pathology

Cementum

Medicine

Regeneration (biology)

Dentistry

Periodontium

Periodontitis

Advanced Healthcare Materials

The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo‐spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of the...

Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives