Advanced Healthcare Materials
IF
9.93
Papers
3,801
Papers 3,680
1 page of 368 pages (3,680 results)
#1Shiyi Huang (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Sijie Li (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Xianting Ding (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 11 authors...
The boosting exploitation of graphene oxide (GO) increases exposure risk to human beings. However, as primary defender in the first immune line, neutrophils' mechanism of defensive behavior towards GO remains unclear. Herein, we discover that neutrophils recognize and defensively degrade GO in a lateral dimension dependent manner. The micrometer-sized GO (mGO) induces NETosis by releasing neutrophil extracellular traps (NETs), while nanometer-sized GO (nGO) elicits neutrophil degranulation. The ...
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#1Liming Lian (BWH: Brigham and Women's Hospital)H-Index: 1
#2Cuiping Zhou (BWH: Brigham and Women's Hospital)H-Index: 1
Last. Yu Shrike Zhang (BWH: Brigham and Women's Hospital)H-Index: 59
view all 16 authors...
The three-dimensional bioprinting technologies have attracted increasing attention due to their flexibility in producing architecturally relevant tissue constructs. Here, we present an enabling vertical embedded extrusion bioprinting strategy using uniaxial or coaxial nozzles, which allows formation of vertical structures of homogeneous or heterogeneous properties in nature. By adjusting the bioprinting parameters, the characteristics of the bioprinted vertical patterns could be precisely contro...
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#1Jie Li (UCB: University of California, Berkeley)H-Index: 10
#2Jan Tuma (UTHSCSA: The University of Texas Health Science Center at San Antonio)H-Index: 1
Last. Niren Murthy (UCB: University of California, Berkeley)H-Index: 50
view all 7 authors...
Protein based therapeutics have the potential to treat a variety of diseases, however, safe and effective methods for delivering them into cells need to be developed before their clinical potential can be realized. Peptide fusions have great potential for improving intracellular delivery of proteins. However, very few peptides have been identified that can increase the intracellular delivery of proteins, and new peptides that can enhance intracellular protein delivery are greatly needed. In this...
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#1Yu-Wei Zhou (ZJU: Zhejiang University)
Macrophages settle in heterogeneous microenvironments consisting of soluble or fixed biochemical components and biophysical clues rendered by other cells and extracellular matrices. It is well known that chemical stimuli direct macrophage behavior; however, the contributions of viscosity, which increase in inflammatory tissues but not in tumors, are ignored in related immune responses including effective activation and timely attenuation. This paper demonstrates that transient lipopolysaccharide...
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#1Yang Yang (Fudan University)H-Index: 162
#2Kaiqi Long (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 3
Last. Changyou Zhan (Fudan University)H-Index: 36
view all 12 authors...
Quantitative drug release is important for improving therapeutic efficiency and avoiding side effects. While using long-term delivery system for repeated therapy, it is indispensable but challenging to accurately control the drug dosing. Herein, a photocleavable prodrug-loaded hydrogel is proposed for near infrared (NIR) light-triggered quantitative pulsed drug release. IR783, a commercially available NIR fluorescent dye, is conjugated with methyl honokiol (mHNK) to give photocleavable IR783-mHN...
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#1Ashna Gopal (University of Edinburgh)H-Index: 2
#2L. Yan (College of Health Sciences, Bahrain)H-Index: 51
Last. Xianfeng Chen (University of Edinburgh)H-Index: 44
view all 7 authors...
With an exponential rise in antimicrobial resistance and stagnant antibiotic development pipeline, there is, more than ever, a crucial need to optimise current infection therapy approaches. One of the most important stage in this process requires rapid and effective identification of pathogenic bacteria responsible for diseases. Current gold standard techniques of bacterial detection include culture methods, polymerase chain reactions, and immunoassays. However, their use is fraught with downsid...
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#2Yanming WangH-Index: 1
Last. Yi Yan YangH-Index: 72
view all 6 authors...
Multidrug resistance infections have plagued the healthcare sector over the past few decades with limited treatment options. To overcome this problem, we synthesized a series of novel guanidinium-functionalized polypeptides. Specifically, poly(ʟ-lysine) (PLL) with different lengths were first synthesized by ring-opening polymerization of NCA followed by functionalization with a guanidinium-functional group to obtain guanidinium-functionalized PLL (PLL-Gua). To study the effect of hydrophobicity ...
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#1Peng Liu (CSU: Central South University)H-Index: 10
#2Xinyi Shi (CSU: Central South University)H-Index: 4
Last. Wenhu Zhou (CSU: Central South University)H-Index: 20
view all 6 authors...
Ferroptosis could activate immune response via inducing tumor cells immunogenic cell death (ICD), and anti-tumor immunity in turn boosts the efficacy of ferroptosis by excreting interferon gamma (IFN-γ), which shows a promising combo for synergistically amplified tumor treatment. However, their combination is strictly limited by the complexity of tumor microenvironment, including poor ferroptosis response and immunosuppressive factors in tumor. Herein, a metal-phenolic networks (MPNs) nanoplatfo...
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#1Yonca Kittel (LG: Leibniz Association)
#2Alexander J. C. Kuehne (LG: Leibniz Association)H-Index: 27
Last. Laura De Laporte (LG: Leibniz Association)H-Index: 23
view all 3 authors...
Microgels are crosslinked polymer networks of finite dimensions in the range of 10 nm to 100 μm. Water-swollen microgels are inherently biocompatible and therefore of interest for biomedical applications. They can be modified chemically or biologically, priming microgels also for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered and tuned on demand by altering the biochemical composition, cro...
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#1Hyejoong Jeong (Yonsei University)H-Index: 15
#2Daheui Choi (Yonsei University)H-Index: 16
Last. Jinkee Hong (Yonsei University)H-Index: 30
view all 5 authors...
The delivery of nitric oxide (NO)-an intrinsic cellular signaling molecule-is promising for disease treatment, in particular to vascular diseases, due to its endothelial-derived inherent nature. The limited diffusion distance of labile NO prompts researchers to develop various carriers and targeting methods for specific sites. In contrast to the apoptotic effect of NO, such as anticancer, delivering low NO concentration at the desired targeting area is still intricate in a physiological environm...
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