Advanced Healthcare Materials
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#1Jiang Maolin (SCUT: South China University of Technology)
#2Kewei Wang (SCUT: South China University of Technology)H-Index: 3
Last. Youyong Yuan (SCUT: South China University of Technology)H-Index: 38
view all 6 authors...
Theranostic prodrugs that can precisely monitor drug activation with synergistic therapeutic effects are highly desirable for personalized medicine. In this study, a theranostic heterodimeric prodrug, CyNH-SS-DOX, with synchronous and independent dual-channel fluorescence turn-on and dual-prodrug activation for synergistic cancer therapy is developed. A hemicyanine fluorescent drug, CyNH2 , with good therapeutic effects found in this work, is conjugated to doxorubicin (DOX) through a disulfide l...
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#1Huan Lei (Northwest University (China))
#2Jing Zhao (Northwest University (China))H-Index: 12
Last. Daidi Fan (Northwest University (China))H-Index: 25
view all 5 authors...
Polymer-based conductive hydrogels have the synergistic advantages of high conductivity and tissue-like properties, making them promising candidates for the construction of flexible electronic devices. However, conductive hydrogel materials can easily absorb microorganisms due to their high water content. To address the problem that conductive hydrogels are susceptible to infection by external pathogens when monitoring wounds and when used in implanted organs, tannic acid-borax (TA-B) complexes ...
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#1Li Zhao ('QUB': Queen's University Belfast)H-Index: 2
#2Chunyang Zhang ('QUB': Queen's University Belfast)H-Index: 1
Last. Ryan F. Donnelly ('QUB': Queen's University Belfast)H-Index: 66
view all 9 authors...
Traditional drug delivery routes possess various disadvantages which make them unsuitable for certain population groups, or indeed unsuitable for drugs with certain physicochemical properties. As a result, a variety of alternative drug delivery routes have been explored in recent decades, including transdermal drug delivery. One of the most promising novel transdermal drug delivery technologies is a microarray patch (MAP), which can bypass the outermost skin barrier and deliver drugs directly in...
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#1Alexander M. Ruhoff (The Heart Research Institute)
#1Alexander M. Ruhoff (USYD: University of Sydney)H-Index: 1
Last. Anna WaterhouseH-Index: 20
view all 7 authors...
Thrombosis on blood-contacting medical devices can cause patient fatalities through device failure and unstable thrombi causing embolism. The effect of material wettability on fibrin network formation, structure, and stability is poorly understood. Under static conditions, fibrin fiber network volume and density increase in clots formed on hydrophilic compared to hydrophobic polystyrene surfaces. This correlates with reduced plasma clotting time and increased factor XIIa (FXIIa) activity. These ...
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#1Bernhard Burtscher (Linköping University)
#2Pamela Allison Manco Urbina (University of Modena and Reggio Emilia)
Last. Daniel Simon (Linköping University)H-Index: 6
view all 11 authors...
An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflamma...
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#1Wei He (HKUST: Hong Kong University of Science and Technology)H-Index: 8
#2Tianfu Zhang (HKUST: Hong Kong University of Science and Technology)H-Index: 3
Last. Ben Zhong TangH-Index: 161
view all 6 authors...
The emergence of the concept of aggregation-induced emission (AIE) has opened new opportunities in many research areas, such as biopsy analysis, biological processes monitoring, and elucidation of key physiological and pathological behaviors. As a new class of luminescent materials, AIE luminogens (AIEgens) possess many prominent advantages such as tunable molecular structures, high molar absorptivity, high brightness, large Stokes shift, excellent photostability, and good biocompatibility. The ...
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#1Yuqing Wang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Bozhang Xia (CAS: Chinese Academy of Sciences)
Last. Xing-Jie Liang (CAS: Chinese Academy of Sciences)H-Index: 80
view all 9 authors...
Considerable efforts have been made into developing aggregation-induced emission fluorogens (AIEgens)-containing nano-therapeutic systems due to the excellent properties of AIEgens. Compared to other fluorescent molecules, AIEgens have advantages including low background, high signal-to-noise ratio, good sensitivity, and resistance to photobleaching, in addition to being exempt from concentration quenching or aggregation-caused quenching effects. The present review outlines the major development...
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#1Bingnan Wang (SCUT: South China University of Technology)
#2Shanshan Liu (SCUT: South China University of Technology)
Last. Tang Bz (SCUT: South China University of Technology)
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The in situ visualization of drugs can improve the understanding of their pharmacokinetics and mechanisms. Aggregation-induced emission (AIE) materials, which can aid in the visualization of drugs, are gradually being employed in pharmaceutical research due to their excellent fluorescence properties, good biocompatibility, and extremely high sensitivity. Herein, the progress of AIE materials in pharmaceutical research, including AIE carriers for drug delivery, AIE multifunctional prodrugs, and A...
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#1Yuji Nashimoto (Tohoku University)H-Index: 10
#2Minori Abe (Tohoku University)
Last. Hitoshi Shiku (Tohoku University)H-Index: 50
view all 9 authors...
Microphysiological systems (MPS) or organs-on-chips (OoC) can emulate the physiological functions of organs in vitro and are effective tools for determining human drug responses in preclinical studies. However, the analysis of MPS has relied heavily on optical tools, resulting in difficulties in real-time and high spatial resolution imaging of the target cell functions. In this study, the role of scanning probe microscopy (SPM) as an analytical tool for MPS is evaluated. An access hole is made i...
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#1Yifeng Shen (SYSU: Sun Yat-sen University)H-Index: 6
#2Congjun Xu (SYSU: Sun Yat-sen University)H-Index: 2
Last. Chunshun Zhao (SYSU: Sun Yat-sen University)H-Index: 9
view all 9 authors...
Due to their great stability and special cavities, metal-organic cages (MOCs) are increasingly considered as promising nanocarriers for drug delivery. However, the size and surface dilemmas restrict their further biomedical applications. The ultrasmall size of MOCs facilitates tumor penetration but suffers from quick clearance and poor accumulation at the tumor site. Hydrophobicity of MOC surfaces improves internalization into tumor cells while causing low blood circulation time as well as poor ...
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Top fields of study
Biomedical engineering
Nanotechnology
Chemistry
Materials science
In vivo
Drug delivery
Tissue engineering