Chitosan nanoparticles as a promising approach for pulmonary delivery of bedaquiline
Abstract
The purpose of the present research work was to explore chitosan nanoparticles (NPs) of a novel anti-tubercular drug, bedaquiline (BDQ) in order to reduce dose and side effects associated with oral BDQ formulation. The NPs were fabricated using ionic gelation method and evaluated for particle size, zeta potential, entrapment efficiency and drug loading. Plackett Burman was used as screening design. Two level three-factor factorial design was...
Paper Details
Title
Chitosan nanoparticles as a promising approach for pulmonary delivery of bedaquiline
Published Date
Nov 1, 2018
Volume
124
Pages
273 - 287
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