European Journal of Pharmaceutical Sciences
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#1Hung Thanh Lam (Can Tho University)H-Index: 8
Last. Andreas Bernkop-SchnürchH-Index: 84
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Abstract Aim The aim of this study was to form hydrophobic ion-pairs of proteinase with cationic surfactants and to incorporate them into self-emulsifying drug delivery systems (SEDDS) to improve their mucus permeating properties. Methods Proteinase was ion-paired with benzalkonium chloride (BAK), hexadecylpyridinium chloride (HDP), alkyltrimethylammonium bromide (ATA) and hexadecyltrimethylammonium bromide (HDT) at pH 8.5-9.0, and subsequently incorporated into SEDDS consisting of Cremophor EL,...
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#1Zahari Vinarov (Katholieke Universiteit Leuven)H-Index: 10
#1Zahari Vinarov (Sofia University)
Last. Patrick Augustijns (Katholieke Universiteit Leuven)H-Index: 72
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ABSTRACT The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populations (age- and disease-dependent), drug and formulation properties, or food-drug interactions. Clinical evidence for the impact of some of these factors on drug pharmacokinetic variability is mounting: e.g. gastric pH and emptying time, smal...
2 CitationsSource
#1Laura J. Henze (UCC: University College Cork)H-Index: 5
#2Niklas J Koehl (Johnson & Johnson)H-Index: 5
Last. Brendan T. Griffin (UCC: University College Cork)H-Index: 27
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Abstract The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine and human intestinal fluids, may impact on the solubility and dissolution behaviour of drugs, in particular BCS II/IV drugs. Recently, a porcine fasted simulated intestinal fluid (FaSSIFp) was developed to mimic the composition in the lumen of landrace pigs under faste...
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#1Natália Kronbauer Oliveira (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 2
#2Luiza Abrahão Frank (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 13
Last. Livia Kmetzsch (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 18
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ABSTRACT Cryptococcus neoformans is the etiological agent of cryptococcal meningoencephalitis. The recommended available treatment has low efficiency, with high toxicity and resistance as recurrent problems. In the search of new treatment protocols, the proposal of new pharmacological approaches is considered an innovative strategy, mainly nanotechnological systems considering fungal diseases. The antiarrhythmic drug amiodarone has demonstrated antifungal activity against a range of fungi, inclu...
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#1Kosuke IshikawaH-Index: 7
Last. Shinya Watanabe (Fukushima Medical University)H-Index: 19
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Abstract Previously, we had established a highly sensitive trap vector system for the efficient isolation of reporter cells for a certain condition of interest. In this study, we used this system to screen reporter cells that express the luciferase and enhanced green fluorescent protein genes in response to dexamethasone, a glucocorticoid receptor agonist to facilitate glucocorticoid signaling research. In total, 10 clones were isolated. The insertion sites of the trap vector were analyzed using...
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#1Giacomo Russo (Edinburgh Napier University)H-Index: 1
#2Giulia Iaccarino (IIT: Istituto Italiano di Tecnologia)H-Index: 3
Last. Rita Santamaria (University of Naples Federico II)H-Index: 23
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Abstract A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an intense antioxidant and antitumoral activity. Unfortunately, its use is severely hampered as this active pharmaceutical ingredient (API) in solution suffers from remarkable instability, which realizes as an interplay of unfolding and aggregatio...
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#1E Valente (University of Lisbon)H-Index: 6
#2Bernard Testa (UNIL: University of Lausanne)H-Index: 84
Last. Luis Constantino (University of Lisbon)H-Index: 12
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Abstract Due to difficulties in drug penetration in M. tuberculosis, a prodrug approach based on mycobacterial activation appears as a promising strategy to increase the delivery of antitubercular drugs to the target microorganisms. Esters have been successful used by us and others to deliver drugs to mycobacteria, however because very little is known about the metabolic hydrolysis of esters by mycobacteria in connection with prodrug activation, we decided to study the process further. For that ...
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#1Nguyen-Thach Tung (Hanoi University)H-Index: 7
#2Cao-Son TranH-Index: 3
Last. Thi-Quyen Tran (Hanoi University)
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This study aimed to investigate the effect of a surfactant on the liquid-liquid phase separation, dissolution, diffusion, and the oral bioavailability of a weakly basic drug (l-tetrahydropalmatine; l-THP) from an amorphous solid dispersion (ASD). The carrier used in the ASD was optimized by the application of casting film, solvent shift, and pH shift methods. The interaction between the optimized carrier (HPMCP) and l-THP was then evaluated by Fourier transform-infrared spectroscopy and powder X...
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#1Sunil Kumar DubeyH-Index: 18
#2Maithili Kali (BITS: Birla Institute of Technology and Science)H-Index: 1
Last. Prashant Kesharwani (Jamia Hamdard)H-Index: 42
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Breast cancer (BC) is a highly heterogeneous malignant carcinoma that is the most frequently occurring cancer in women. The major types of BC are luminal A, basal-like, luminal B, human epidermal growth factor receptor 2 (HER2) positive/ estrogen receptor (ER) negative, and triple-negative BC (TNBC). The conventional therapies against BC include various chemotherapeutic agents in different combinations. Along with the chemotherapeutic drugs, alternatives like hormonal therapy, radiation, and nan...
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