European Journal of Pharmaceutical Sciences
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Papers 6797
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#1Sara Bahrainian (Tehran University of Medical Sciences)H-Index: 2
#2Maryam Sadat Mirmoeini (Tehran University of Medical Sciences)
Last. Kambiz Gilani (Tehran University of Medical Sciences)H-Index: 26
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Abstract null null The aim of this work was to study the effect of concomitant use of leucine and dipalmitoylphosphatidylcholine, in different ratios, on aerosolization performance of levodopa. Three-component formulations were selected based on a central composite design using percentages of leucine and dipalmitoylphosphatidylcholine as the independent variables. Particle size, surface roughness index, surface phosphorus and fine particle fraction were considered as dependent variables in the m...
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#1Si-Qi Ma (Peking Union Medical College)H-Index: 3
#2Zhao-Qing Cong (Peking Union Medical College)H-Index: 3
Last. Yong-Hong Liao (Peking Union Medical College)H-Index: 20
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Abstract null null Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery. However, the differentiation of NPCs to oligodendrocytes in 3D scaffolds remains a great challenge. In this study, polyvinyl alcohol (PVA) − sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions. It was demonstrated ...
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#2Chenlu Hu (CPU: China Pharmaceutical University)
Last. Huixia Lv (CPU: China Pharmaceutical University)H-Index: 19
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Abstract null null Triple negative breast cancer (TNBC) is the most dangerous subtype of breast cancer accompanying by unfavorable prognosis due to lack of specific therapeutic targets. Paclitaxel (PTX) is the first-line chemotherapeutic drug for TNBC and niclosamide (NLM) was identified as an inhibitor for TNBC and breast cancer stem cells (BCSCs). Intratumoral drug delivery system was a hopeful alternative for chemotherapeutic drug administration due to its targeting efficiency with lower syst...
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#1Wang Dan (Lanzhou University)H-Index: 3
#2Lu Cheng (Lanzhou University)H-Index: 2
Last. Junqiu Xie (Lanzhou University)H-Index: 2
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Abstract null null Pulmonary fibrosis is a chronic progressive lung disease that lacks effective treatments in clinic. It is characterized by repair disorder of epithelial cells, formation of fibroblast foci as well as destruction of alveolar structure. Previously we first determined that parent peptide DR8 (DHNNPQIR-NH2) has anti-fibrotic activity in bleomycin-induced mice. In order to further improve the druggability of DR8, including anti-fibrotic activity, stability and security, the structu...
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#1Xian-min Meng (Fudan University)
#2Zi-ran Li (Fudan University)
Last. Hong-zhou Lu (Fudan University)
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Abstract null null Background null Efavirenz is a vital component used to treat HIV-1 infection. Nevertheless, it shows large between-subject variability, which affects both its therapeutic response and adverse effects. null null null Objective null To investigate the impact of gene polymorphisms and non-genetic factors on the variability of efavirenz pharmacokinetics and to propose the optimal dose regimens. null null null Methods null A total of 769 plasma samples from 376 HIV-infected Han Chi...
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#1Salah M. Seif (Beni-Suef University)H-Index: 1
#2Mohamed El-Nady (Cairo University)H-Index: 4
Last. Mohamed E.A. Abdelrahim (Beni-Suef University)H-Index: 21
view all 5 authors...
Abstract null null Aerosol delivery to mechanically ventilated patients requires add-on connections to place the inhalation device within the ventilation circuit. The study aimed to evaluate the performance of Combihaler in dual limb invasive mechanical ventilation (IMV). null A ventilator with a humidified dual limb circuit was adjusted to volume-controlled mode to imitate the adult breathing parameters. 24 (12 females) intubated chronic obstructive pulmonary disease (COPD) subjects had undergo...
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#1Samaneh Alaei (NSU: Nova Southeastern University)H-Index: 2
#2Yadollah Omidi (NSU: Nova Southeastern University)H-Index: 51
Last. Hamid Omidian (NSU: Nova Southeastern University)H-Index: 7
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Abstract null null Oral drug delivery is often challenged with enzymatic degradation of drug molecules in the gastrointestinal tract and high first-pass metabolism, resulting in low bioavailability. Delivery of drug molecules via the oral cavity mucosa is considered a viable option to enhance bioavailability. One of the relatively new dosage forms for transmucosal drug delivery is the oral thin film (OTF) with mucoadhesive properties that offers several advantages over conventional dosage forms,...
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#1Susi Burgalassi (UniPi: University of Pisa)H-Index: 27
Last. Marco Verani (UniPi: University of Pisa)H-Index: 20
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Abstract null null The release of quality, safe, and effective non-sterile drugs needs to exclude the presence of objectionable microorganisms, which include microorganisms potentially involved in product degradation, or considered as poor hygiene indicator during manufacturing, or causing adverse effect on patient's health. In this paper, a method allowing objective and verifiable evaluations has been investigated through the development of a suitable decision tree with a template for data coll...
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#1Rangrang Fan (Sichuan University)H-Index: 14
#2Di Chuan (Sichuan University)H-Index: 3
Last. Gang Guo (Sichuan University)H-Index: 34
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Abstract null null Purpose null : Dexamethasone (Dex) is a widely used drug for the treatment of inflammatory and autoimmune conditions, however, long-term systemic use of Dex is associated with serious adverse effects. The objective of the present study was to develop an implantable device to avoid side effects and realize a controlled release of Dex at the implant site. null null null Methods null : Hydrophobic Dex was incorporated into biodegradable polyesters derived from PCL and Pluronic® L...
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#1Jovana Panić (University of Novi Sad)H-Index: 9
#2Aleksandar Tot (University of Novi Sad)H-Index: 14
Last. Milan Vraneš (University of Novi Sad)H-Index: 17
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Abstract null null The present work focuses on modifying a local anaesthetic drug procaine into an ionic liquid and evaluating the resulting thermal behaviour and structural changes. Counter ions, salicylate, ibuprofenate, and docusate, were chosen due to different hydrogen-bonding abilities, molecular size, charge distribution, and functional groups. After synthesis of procaine salicylate, procaine ibuprofenate, and procaine docusate, spectroscopic investigations were performed using infrared (...
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