Genomic instability in mutant p53 cancer cells upon entotic engulfment

Volume: 9, Issue: 1
Published: Aug 3, 2018
Abstract
Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of host cells and for cells without p53 this leads to host cell death. In contrast, mutant p53 host cells survive, display aberrant divisions,...
Paper Details
Title
Genomic instability in mutant p53 cancer cells upon entotic engulfment
Published Date
Aug 3, 2018
Volume
9
Issue
1
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