Original paper
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors
Abstract
Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacological targeting of inhibitory α2 and α3GABAA receptors reduces acute histaminergic and non-histaminergic itch in mice. Systemic treatment with an...
Paper Details
Title
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors
Published Date
Aug 7, 2018
Journal
Volume
9
Issue
1