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Original paper

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Volume: 9, Issue: 1
Published: Jul 9, 2018
Abstract
Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Using a novel RNA replicon-based vaccine, we show the impact of PMIF immunoneutralization on the host response and observed improved control of liver and blood-stage Plasmodium infection, and complete protection from re-infection. Vaccination against PMIF delayed blood-stage patency after...
Paper Details
Title
Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
Published Date
Jul 9, 2018
Volume
9
Issue
1
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