Original paper
Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
Abstract
Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Using a novel RNA replicon-based vaccine, we show the impact of PMIF immunoneutralization on the host response and observed improved control of liver and blood-stage Plasmodium infection, and complete protection from re-infection. Vaccination against PMIF delayed blood-stage patency after...
Paper Details
Title
Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
Published Date
Jul 9, 2018
Journal
Volume
9
Issue
1