Development of an isotoxic decision support system integrating genetic markers of toxicity for the implantation of a rectum spacer

Published on Jun 28, 2018in Acta Oncologica3.701
· DOI :10.1080/0284186X.2018.1484156
Yvonka van Wijk4
Estimated H-index: 4
(Maastricht University Medical Centre),
Ben G. L. Vanneste14
Estimated H-index: 14
(UM: Maastricht University)
+ 6 AuthorsPhilippe Lambin113
Estimated H-index: 113
(Maastricht University Medical Centre)
AbstractIntroduction: Previous studies revealed that dose escalated radiotherapy for prostate cancer patients leads to higher tumor control probabilities (TCP) but also to higher rectal toxicities. An isotoxic model was developed to maximize the given dose while controlling the toxicity level. This was applied to analyze the effect of an implantable rectum spacer (IRS) and extended with a genetic test of normal tissue radio-sensitivity. A virtual IRS (V-IRS) was tested using this method. We hypothesized that the patients with increased risk of toxicity would benefit more from an IRS.Material and methods: Sixteen localized prostate cancer patients implanted with an IRS were included in the study. Treatment planning was performed on computed tomography (CT) images before and after the placement of the IRS and with a V-IRS. The normal tissue complication probability (NTCP) was calculated using a QUANTEC reviewed model for Grade > =2 late rectal bleeding and the number of fractions of the plans were adjusted ...
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