Acta Oncologica
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#1L. Toussaint (Aarhus University Hospital)H-Index: 3
#2Sarah PetersH-Index: 50
Last. Beate TimmermannH-Index: 26
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BACKGROUND Survivors of pediatric brain tumors are susceptible to neurovascular disease after radiotherapy, with dose to the chiasm or Circle of Willis (CW) as risk factors. The aims of this study were to develop a delineation atlas of neurovascular structures, to investigate the doses to these structures in relation to tumor location and to investigate potential dose surrogates for the CW dose. MATERIAL AND METHODS An atlas of the CW, the large intracranial arteries and the suprasellar cistern ...
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#1Juliet Jacobsen (Harvard University)H-Index: 18
#2Maria E. C. Schelin (Lund University)H-Index: 5
Last. Carl Johan Fürst (Lund University)H-Index: 26
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According to ASCO guidelines, cancer-directed treatment should be avoided in the last month of life. However, Mattsson et al. (this issue) demonstrate that 16% of Danish patients receive such treat...
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#2Etienne BuscailH-Index: 11
Last. Christophe LaurentH-Index: 68
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BACKGROUND Neoadjuvant treatment (NAT) is debated for borderline resectable pancreatic cancer (BRPC). This retrospective study assessed the impact of NAT on R0 rate and survival for BRPC patients in comparison with upfront surgery (US). MATERIAL AND METHODS Between 2010 and 2017 patient records for all consecutive patients treated for BRPC according to NCCN 2017 were reviewed. The endpoints analysed were R0 rate, recurrence-free-survival (RFS) and overall survival (OS). RESULTS Seventy-nine pati...
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#1Joyce E. Lodeweges (UU: Utrecht University)H-Index: 1
#2Peter S.N. van Rossum (UU: Utrecht University)H-Index: 15
Last. Joost J.C. Verhoeff (UU: Utrecht University)H-Index: 15
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For patients with early stage or medically inoperable lung cancer, stereotactic body radiotherapy (SBRT) is a general accepted and effective treatment option. The role of SBRT in ultra-central tumo...
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#1Pauliina Wright (TYKS: Turku University Hospital)H-Index: 3
Last. Eirik Malinen (University of Oslo)H-Index: 22
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BACKGROUND Hypoxia dose painting is a radiotherapy technique to increase the dose to hypoxic regions of the tumour. Still, the clinical effect relies on the reproducibility of the hypoxic region shown in the medical image. 18F-EF5 is a hypoxia tracer for positron emission tomography (PET), and this study investigated the repeatability of 18F-EF5-based dose painting by numbers (DPBN) in head and neck cancer (HNC). MATERIALS AND METHODS Eight HNC patients undergoing two 18F-EF5-PET/CT sessions (A ...
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#1Lucy Gately (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 2
#2Azim Jalali (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 2
Last. Grace Gard (WEHI: Walter and Eliza Hall Institute of Medical Research)
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BACKGROUND Multiple meta-analyses have demonstrated that routine surveillance following colorectal cancer surgery improves survival outcomes. There is limited data on how recurrence patterns and post-recurrence outcomes vary by individual tumor stage. METHODS Using a multi-site community cohort study, we examined the potential impact of primary tumor stage on the sites of recurrence, management of recurrent disease with curative intent, and post-resection survival. We also explored changes over ...
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#1Ricardo García-Fumero (UGR: University of Granada)
#2Cristina Fernández-López (UGR: University of Granada)H-Index: 1
Last. José Expósito-Hernández (UGR: University of Granada)H-Index: 2
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BACKGROUND Despite newer therapies, advanced or metastatic non-small-cell lung cancer (NSCLC) continues to be the leading cause of cancer-related deaths worldwide. Deficits in the design and methods of randomized controlled trials (RCTs) may contribute to reducing the clinical benefit of therapies in oncology. To prioritize treatments based on efficacy results and toxicity data, the European Society for Medical Oncology (ESMO) has developed the Magnitude of Clinical Benefit Scale (MCBS). The obj...
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#1Eero PukkalaH-Index: 116
#2Miikka Peltomaa (University of the Arts Helsinki)H-Index: 5
Last. Elisabete Weiderpass (IARC: International Agency for Research on Cancer)H-Index: 137
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There are studies suggesting that participation in musical activities may protect from cancer. On the other hand, some musicians have a lifestyle that might increase the risk of cancer. The objecti...
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#1Annika Patthey (Umeå University)H-Index: 2
#2K. Boman (Umeå University)H-Index: 12
Last. Magnus Hultdin (Umeå University)H-Index: 16
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INTRODUCTION Endometrioid endometrial carcinoma is a cancer type with generally excellent prognosis when diagnosed at an early stage, but there is a subset of patients with relapsing disease in spite of early diagnosis and surgical treatment. There is a need to find prognostic markers to identify these patients with increased risk of relapse. Depth of myometrial invasion, histological grade, and presence of lymphovascular invasion are known risk factors. DNA content (ploidy) and proliferation me...
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#1Chukwuka Eze (LMU: Ludwig Maximilian University of Munich)H-Index: 11
#2Julian Taugner (LMU: Ludwig Maximilian University of Munich)H-Index: 6
Last. Claus Belka (LMU: Ludwig Maximilian University of Munich)H-Index: 73
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Concurrent platinum-based chemoradiation (CRT) followed by consolidation PD-L1 inhibition with durvalumab is the standard of care for patients with inoperable stage III NSCLC [1]. However, in high-...
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