RONC-14. REPLICATING CLINICAL RADIATION THERAPY PROTOCOLS IN PRECLINICAL BRAIN TUMOUR MODELS

Surgical resection and radiotherapy, often followed by chemotherapy, have been the mainstay of paediatric brain cancer treatment for decades. For brain cancers with a predilection to spread throughout the brain and spinal cord, such as medulloblastoma, craniospinal irradiation represents the standard-of-care. An unavoidable consequence of this is collateral damage of healthy tissue, resulting in potentially devastating long-term sequelae,...