Neuro-oncology
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#1Norbert Galldiks (University of Cologne)H-Index: 46
#2Maximilian Niyazi (LMU: Ludwig Maximilian University of Munich)H-Index: 29
Last. Karl-Josef Langen (Forschungszentrum Jülich)H-Index: 59
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#1Rupesh Kotecha (Baptist Hospital of Miami)H-Index: 20
#2Mariam Aboian (Yale University)H-Index: 2
Last. Samuel T. Chao (Cleveland Clinic Lerner College of Medicine)H-Index: 5
view all 6 authors...
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#1Katja von Hoff (Charité)H-Index: 29
#2Christine Haberler (Medical University of Vienna)H-Index: 29
Last. Marcel KoolH-Index: 91
view all 61 authors...
BACKGROUND Only few data are available on treatment-associated behavior of distinct rare CNS-embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors" (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumor with multi-layered rosettes (ETMR) are needed for development of differentiated treatment strategies. METHODS Within this retrospective, international study, tumor samples of clinically well...
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#1John P. Marinelli (Mayo Clinic)H-Index: 8
#2Matthew L. Carlson (Mayo Clinic)H-Index: 32
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#1Julie Boyer (University of Paris)
#2Cristina Birzu (University of Paris)H-Index: 3
Last. Ahmed Idbaih (University of Paris)H-Index: 63
view all 7 authors...
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#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Shoudong Li (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Frederick F. Lang (University of Texas MD Anderson Cancer Center)H-Index: 77
view all 13 authors...
BACKGROUND Oncolytic adenoviruses are promising new treatments against solid tumors, particularly for glioblastoma (GBM), and preclinical models are required to evaluate the mechanisms of efficacy. However, due to the species selectivity of adenovirus, there is currently no single animal model that supports viral replication, tumor oncolysis, and a virus-mediated immune response. To address this gap, we took advantage of the Syrian hamster to develop the first intracranial glioma model that is b...
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#1Silvia ScocciantiH-Index: 18
#2Emanuela OlmettoH-Index: 9
Last. Lorenzo LiviH-Index: 28
view all 30 authors...
BACKGROUND To define efficacy and toxicity of Immunotherapy (IT) with stereotactic radiotherapy (SRT) including radiosurgery (RS) or hypofractionated SRT (HFSRT) for brain metastases (BM) from Non-Small Cell Lung Cancer (NSCLC) in a multicentric retrospective study from AIRO (Italian Association of Radiotherapy and Clinical Oncology). METHODS NSCLC patients with BM receiving SRT+IT and treated in 19 Italian centers were analysed and compared with a control group of patients treated with exclusiv...
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#1Bianca Maria Marin (Mayo Clinic)H-Index: 1
#2Kendra A Porath (Mayo Clinic)
Last. Jann N. Sarkaria (Mayo Clinic)H-Index: 66
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BACKGROUND Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. Understanding the mechanisms of failure for this promising strategy is critically important. METHODS PDX models were employed to study efficacy of systemic vs intracranial delivery of Depatux-M. Immunofluorescence and MALDI-MSI wer...
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#1Niels Verburg (VU: VU University Amsterdam)H-Index: 6
#2Floris P. BarthelH-Index: 12
Last. Roel G W Verhaak (VU: VU University Amsterdam)
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BACKGROUND Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence. METHODS We used neuronavigation to acquire 133 image-guided and spatially-separated stereotactic biopsy samples from 16 adult patients with a diffuse glioma (7 IDH-wildtype and 2 IDH-mutant glioblastoma, 6 diffuse ast...
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#1Milena Simovic (DKFZ: German Cancer Research Center)H-Index: 2
#2Michiel Bolkestein (DKFZ: German Cancer Research Center)H-Index: 1
Last. Aurélie Ernst (DKFZ: German Cancer Research Center)H-Index: 16
view all 24 authors...
BACKGROUND Medulloblastomas with chromothripsis developing in children with Li-Fraumeni Syndrome (germline TP53 mutations) are highly aggressive brain tumors with dismal prognosis. Conventional photon radiotherapy and DNA-damaging chemotherapy are not successful for these patients and raise the risk of secondary malignancies. We hypothesized that the pronounced homologous recombination deficiency in these tumors might offer vulnerabilities that can be therapeutically utilized in combination with...
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