Genetic compensation of RUNX family transcription factors in leukemia

Runt (Runt domain)‐related transcription factor 1 ( RUNX 1) is a transcription factor belonging to the core‐binding factor ( CBF ) family. It is considered to be a master regulator of hematopoiesis and has been regarded as a tumor suppressor because it is essential for definitive hematopoiesis in vertebrates. It is one of the most frequent target genes of chromosomal translocation in leukemia, and germ line mutation of RUNX 1 causes familial...