Yasuhiko Kamikubo
Kyoto University
HaematopoiesisInternal medicinePathologyOncologyMolecular biologyChemistryHematologyProgenitor cellImmunologyRUNX1LeukemiaMyeloid leukemiaMyeloidLymphomaBone marrowMYH11MutationCancer researchMedicineTranscription factorBiology
Publications 80
#1Hirohito Kubota (Kyoto University)H-Index: 1
#2Tatsuya Masuda (Kyoto University)
Last. Yasuhiko Kamikubo (Kyoto University)H-Index: 14
view all 15 authors...
#1Mitsuhito Hirano (UTokyo: University of Tokyo)H-Index: 2
#2Yoichi Imai (UTokyo: University of Tokyo)H-Index: 31
Last. Arinobu Tojo (UTokyo: University of Tokyo)H-Index: 51
view all 20 authors...
Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the bioactivities of IMiDs such as lenalidomide. Moreover, genetic alteration of CRBN is frequently detected in IMiD-resistant patients and is considered to contribute to IMiD resistance. Thus, overcoming resistance to drugs, including IMiDs, is expected to improve clinical outcomes. Here, we ...
#1Yasuhiko Kamikubo (Kyoto University)H-Index: 14
#2Atsushi Takahashi (Kibi International University)H-Index: 1
The second and third waves of SARS-CoV-2 epidemic have peaked out and vaccination has begun worldwide. In this study, ecological studies comparing viral genotypes and epidemiological information revealed that the virus was attenuated in the second wave and that three new variants increased CFR in the third wave. In Russia, the infection was widespread in areas with high GDP per capita, such as sparsely populated oil field areas and densely populated metropolitan areas. In New Zealand, CFR, preva...
#1Kana Nakatani (Kyoto University)H-Index: 7
#2Hidemasa Matsuo (Kyoto University)H-Index: 9
Last. Souichi Adachi (Kyoto University)H-Index: 40
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The t(8;21) translocation is the most common cytogenetic abnormality in acute myeloid leukemia (AML). Although t(8;21) AML patients have a relatively favorable prognosis, relapse is a frequent occurrence, underscoring the need to develop novel therapeutic approaches. Here, we showed that t(8;21) AML is characterized by frequent mutation and overexpression of CCND2. Analysis of 19 AML cell lines showed that t(8;21) AML cells had lower IC50 values for the selective CDK4/6 inhibitors palbociclib an...
#1Tomoo Daifu (Kyoto University)H-Index: 2
#2Masamitsu Mikami (Kyoto University)H-Index: 4
Last. Yasuhiko Kamikubo (Kyoto University)H-Index: 14
view all 23 authors...
Malignant rhabdoid tumor (MRT) is a rare and highly aggressive pediatric malignancy primarily affecting infants and young children. Intensive multimodal therapies currently given to MRT patients are not sufficiently potent to control this highly malignant tumor. Therefore, additive or alternative therapy for these patients with a poor prognosis is necessary. We herein demonstrated that the inhibition of runt-related transcription factor 1 (RUNX1) by novel alkylating conjugated pyrrole-imidazole ...
#1Hiroaki Maki (UTokyo: University of Tokyo)H-Index: 4
#2Akihide Yoshimi (UTokyo: University of Tokyo)H-Index: 27
Last. Mineo Kurokawa (UTokyo: University of Tokyo)H-Index: 69
view all 8 authors...
Abstract BAALC is identified as a leukemia-associated gene and is highly expressed in CD34 positive hematopoietic stem cells. High BAALC expression is associated with poor prognosis in several types of acute myeloid leukemia. We explored binding partner proteins of BAALC by means of mass spectrometry and analyzed biological properties of BAALC expressing leukemic cells. We revealed that BAALC physically interacts with DBN1, which is an actin-binding protein and promotes cell adhesion and mobilit...
#1Takayuki Hamabata (Kyoto University)H-Index: 3
#2Katsutsugu Umeda (Kyoto University)H-Index: 15
Last. Toshio Heike (Kyoto University)H-Index: 58
view all 24 authors...
#1Hidemasa Matsuo (Kyoto University)H-Index: 9
#2Tomohiro Wakita (Kyoto University)
Last. Souichi Adachi (Kyoto University)H-Index: 40
view all 14 authors...
#1Yasuhiko Kamikubo (Kyoto University)H-Index: 14
#2Toshio Hattori (Kibi International University)H-Index: 31
Last. Atsushi Takahashi (Kibi International University)H-Index: 1
view all 3 authors...
The world has been plagued by complex waves of SARS-CoV-2 epidemics that vary from region to region, leaving the end of the pandemic unpredictable. Here we performed "genetic fingerprinting" to compare the local viral genotypes with epidemiological information and reveal the molecular dynamics of the SARS-CoV-2 epidemic worldwide. A multifaceted analyses of the epidemic trends and their relationship to virus genotypes, regional herd immunity, population density, and race has shown that epidemic ...
1 CitationsSource
#1Etsuko Yamamoto (Kyoto University)
#2Yoshiki Arakawa (Kyoto University)H-Index: 27
Last. Yasuhiko Kamikubo (Kyoto University)H-Index: 14
view all 9 authors...