Cancer Science
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#1Kaoru Murakami (Kyoto University)H-Index: 2
#2Yuki Kita (Kyoto University)H-Index: 4
Last. Takayuki Goto (Kyoto University)H-Index: 12
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Overcoming cisplatin (CDDP) resistance is a major issue in urothelial cancer (UC), in which CDDP-based chemotherapy is the first-line treatment. WEE1, a G2/M checkpoint kinase, confers chemo-resistance in response to genotoxic agents. However, the efficacy of WEE1 blockade in UC has not been reported. MK-1775, a WEE1 inhibitor also known as AZD-1775, blocked proliferation of UC cell lines in a dose-dependent manner irrespective of TP53 status. MK-1775 synergized with CDDP to block proliferation,...
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#1Marija Mojic (University of Toyama)H-Index: 1
#2Kiyomi ShitaokaH-Index: 4
Last. Yoshihiro Hayakawa (University of Toyama)H-Index: 51
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For successful immunotherapy for cancer, it is important to understand the immunological status of tumor antigen-specific CD8+ T cells in the tumor microenvironment during tumor progression. In this study, we monitored the behavior of B16OVA-Luc cells in mice immunized with a model tumor antigen OVA. Using bioluminescent imaging, we identified the time-series of OVA-specific CD8+ T-cell responses during tumor progression: initial progression, immune control, and the escape phase. As a result of ...
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#1Yunxiong Wei (Tianjin Medical University)H-Index: 1
#2Xia Xiong (Tianjin Medical University)H-Index: 1
Last. Tongtong Sun (Tianjin Medical University)
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Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are usually associated with poor outcomes, especially in high-risk AML/MDS. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative option for patients suffering from high-risk AML/MDS. However, many patients relapse after allo-HSCT. Novel therapy to prevent relapse is urgently needed. Both the BCL-2 inhibitor venetoclax (VEN) and the hypomethylating agent decitabine (DEC) possess significant antitumor ac...
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#1Julie E. Burns (University of Leeds)
#2Carolyn D. Hurst (University of Leeds)H-Index: 24
Last. Simon J Allison (University of Huddersfield)
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Bladder cancer is the 10th most common cancer worldwide. For muscle-invasive bladder cancer (MIBC), treatment includes radical cystectomy, radiotherapy and chemotherapy, however, outcome is generally poor. For non-muscle-invasive bladder cancer (NMIBC), tumor recurrence is common. There is an urgent need for more effective and less harmful therapeutic approaches. Here, bladder cancer cell metabolic reprogramming to rely on aerobic glycolysis (the Warburg effect) and expression of associated mole...
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#1Susumu Ohya (Nagoya City University)H-Index: 34
#2Junko Kajikuri (Nagoya City University)H-Index: 11
Last. Takayoshi Suzuki (Osaka University)H-Index: 27
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The large-conductance Ca2+ -activated K+ channel KCa 1.1 plays a pivotal role in tumor development and progression in several solid cancers. The three-dimensional (3D) in vitro cell culture system is a powerful tool for cancer spheroid formation, and mimics in vivo solid tumor resistance to chemotherapy in the tumor microenvironment (TME). KCa 1.1 is functionally expressed in osteosarcoma and chondrosarcoma cell lines. KCa 1.1 activator-induced hyperpolarizing responses were significantly larger...
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#1Guo Zhengjun (CQMU: Chongqing Medical University)
#2Kai Zhou (Third Military Medical University)
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Despite considerable efforts in the detection and treatment of gastric cancer (GC), the underlying mechanism of the progression of GC remains unknown. Our previous work has demonstrated the remarkable role of Runt-related transcription factor 2 (RUNX2), in fueling the invasion and metastasis of GC. The present study aimed to elucidate the role of RUNX2 in tumorigenesis of GC. We assessed Runx2 expression and its clinical significance via bioinformatic analysis of the Cancer Genome Atlas and Gene...
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#1Koji IzutsuH-Index: 36
#2Kiyoshi Ando (Tokai University)H-Index: 53
Last. Rika SakaiH-Index: 16
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Tazemetostat is a selective, reversible, small-molecule inhibitor of the histone methyltransferase enzyme, enhancer of zest homolog 2 (EZH2). In this multicenter, open-label, phase II study, we assessed the efficacy and safety of tazemetostat in Japanese patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma harboring the EZH2 mutation. Tazemetostat (800 mg twice daily) was given orally (28-day cycle) until disease progression or unacceptable toxicity. Among the 20 eligible patie...
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#1Yoshikane Kikushige (Kyushu University)H-Index: 20
Acute myeloid leukemia (AML) is hierarchically organized by self-renewing leukemic stem cells (LSCs). LSCs originate from hematopoietic stem cells (HSCs) by acquiring multistep leukemogenic events. To specifically eradicate LSCs, while keeping normal HSCs intact, the discrimination of LSCs from HSCs is important. We have identified T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) as an LSC-specific surface molecule in human myeloid malignancies and demonstrated its essential function ...
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#1Dafei Chai (Xuzhou Medical College)H-Index: 5
#2Zichun Zhang (Xuzhou Medical College)
Last. Hui Tian (Xuzhou Medical College)H-Index: 11
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Renal carcinoma shows a high risk of invasion and metastasis without effective treatment. Herein, we developed a chitosan (CS) nanoparticle-mediated DNA vaccine containing an activated factor L-Myc and a tumor-specific antigen CAIX for renal carcinoma treatment. The subcutaneous tumor models were intramuscularly immunized with CS-pL-Myc/pCAIX or control vaccine, respectively. Compared with single immunization group, the tumor growth was significantly suppressed in CS-pL-Myc/pCAIX co-immunization...
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#1Yuanxin Tang (PRC: China Medical University (PRC))
#2Taifang Wang (PRC: China Medical University (PRC))H-Index: 1
Last. Chunli Wu (PRC: China Medical University (PRC))H-Index: 1
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Clinical reports indicate that gastric cancer (GC) has a high mortality rate, while its pathological mechanism is largely unknown remains poorly understood. This work integrated bioinformatics analysis with experimental verification to explore novel biomarkers of gastric cancer. First, weighted gene co-expression network analysis was applied to screen significant genes correlated with GC development. Besides, gene set enrichment analysis was used to unearth the most relevant biological functions...
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