Cancer Science
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6.72
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5,635
Papers 5,523
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#1Emi Ikebe (NIH: National Institutes of Health)H-Index: 6
#2Shunsuke Shimosaki (University of Miyazaki)H-Index: 5
Last. Kazuhiro Morishita (University of Miyazaki)H-Index: 31
view all 12 authors...
ATL (adult T-cell leukemia/lymphoma) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by the HTLV-1 (human T-cell leukemia virus type 1) infection and there is an urgent need for more effective therapeutic options. The molecular chaperone HSP90 (heat shock protein 90) plays a crucial role in NF-κB (nuclear factor κB)-mediated anti-apoptosis in ATL cells, and HSP90 inhibitors are new candidate therapeutics for ATL. Accordingly, we investigated the anti-ATL effects of a nov...
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#1Motoki IwasakiH-Index: 90
#2Rieko KaneharaH-Index: 2
Last. Takahisa MatsudaH-Index: 64
view all 15 authors...
Escherichia coli containing polyketide synthase in the gut microbiota (pks+ E coli) produce a polyketide-peptide genotoxin, colibactin, and are suspected to play a role in the development of colorectal neoplasia. To clarify the role of pks+ E coli in the early stage of tumorigenesis, we investigated whether the pks status of E coli was associated with the prevalence of colorectal neoplasia. This cross-sectional analysis of data from a prospective cohort in Izu Oshima, Japan included asymptomatic...
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#1Peng-Cheng Wang (Fudan University)H-Index: 4
#2Zhi-Qiang Hu (Fudan University)H-Index: 13
Last. Xiao-Wu Huang (Fudan University)H-Index: 26
view all 9 authors...
Infiltrating immune cells in the tumor microenvironment (TME) influence tumor progression and patient prognosis, making them attractive therapeutic targets for immunotherapy research. A deeper understanding of immune cell distributions in the TME in hepatocellular carcinoma (HCC) is needed to identify interactions among different immune cell types that might impact the effectiveness of potential immunotherapies. We performed multiplex immunohistochemistry using a tissue microarray of samples fro...
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#1Wei-Chao Liao (CGU: Chang Gung University)H-Index: 7
#2Tsung-Jen Lin (CGU: Chang Gung University)
view all 14 authors...
Lung adenocarcinoma (ADC) is the predominant histological type of lung cancer, and radiotherapy is one of the current therapeutic strategies for lung cancer treatment. Unfortunately, biological complexity and cancer heterogeneity contribute to radioresistance development. Karyopherin α2 (KPNA2) is a member of the importin α family that mediates the nucleocytoplasmic transport of cargo proteins. KPNA2 overexpression is observed across cancer tissues of diverse origins. However, the role of KPNA2 ...
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#1Kazuo Okadome (Kumamoto University)H-Index: 7
#2Yoshifumi Baba (Kumamoto University)H-Index: 53
Last. Hideo Baba (Kumamoto University)H-Index: 99
view all 16 authors...
Immune checkpoint inhibitors have shown efficacy in various cancers. Although PD-L1/L2 expressions have been demonstrated as predictive biomarkers of response to immune checkpoint inhibitors and prognostic markers, whether PD-L1/L2 expression is altered in esophageal squamous cell carcinoma during the therapeutic course is unclear. Whether PD-L1/L2 expression in metastatic or recurrent lesions is consistent with that in primary tumors is also unknown. This study included 561 surgically resected ...
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#1Supeng Shen (HMU: Hebei Medical University)H-Index: 12
#2Jia Liang (HMU: Hebei Medical University)H-Index: 10
Last. Zhiming Dong (HMU: Hebei Medical University)H-Index: 19
view all 8 authors...
Dysregulation of long noncoding RNA SNHG17 is associated with the occurrence of several tumors; however, its role in esophageal squamous cell carcinoma (ESCC) remains obscure. The present study demonstrated that SNHG17 was upregulated in ESCC tissues and cell lines, induced by TGF-β1, and associated with poor survival. It is also involved in the epithelial-to-mesenchymal transition (EMT) process. The mechanism underlying SNHG17-regulated c-Myc was detected by RNA immunoprecipitation, RNA pull-do...
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#1Isamu HoshinoH-Index: 23
#2Hajime Yokota (Chiba University)H-Index: 13
Last. Hiroki NagaseH-Index: 27
view all 12 authors...
Tumor mutational burden (TMB) is gaining attention as a biomarker for responses to immune checkpoint inhibitors in cancer patients. In this study, we evaluated the status of TMB in primary and liver metastatic lesions in patients with colorectal cancer (CRC). In addition, the status of TMB in primary and liver metastatic lesions was inferred by radiogenomics on the basis of computed tomography (CT) images. The study population included 24 CRC patients with liver metastases. DNA was extracted fro...
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#1Kensuke Koike (Kyushu University)H-Index: 4
#2Takaaki Masuda (Kyushu University)H-Index: 18
Last. Takashi NakagawaH-Index: 25
view all 16 authors...
Colorectal cancer (CRC) is one of the most common types of cancer and a significant cause of cancer mortality worldwide. Further improvements of CRC therapeutic approaches are needed. BCL2-associated athanogene 6 (BAG6), a multifunctional scaffold protein, plays an important role in tumor progression. However, regulation of BAG6 in malignancies remains unclear. This study showed that guided entry of tail-anchored proteins factor 4 (GET4), a component of the BAG6 complex, regulates the intercellu...
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#1Hong Shik YunH-Index: 10
#2Janet S. LeeH-Index: 41
Last. Sang-Gu HwangH-Index: 25
view all 11 authors...
To improve the poor survival rate of lung cancer patients, we investigated the role of HDGF-related protein 3 (HRP-3) as a potential biomarker for lung cancer. The expression of endogenous HRP-3 in human lung cancer tissues and xenograft tumor models is indicative of its clinical relevance in lung cancer. Additionally, we demonstrated that HRP-3 directly binds to the E2F1 promoter on chromatin. Interestingly, HRP-3 depletion in A549 cells impedes the binding of HRP-3 to the E2F1 promoter; this i...
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#1Hideyuki Takahashi (Gunma University)H-Index: 10
#2Koichi Sakakura (Gunma University)H-Index: 18
Last. Kazuaki Chikamatsu (Gunma University)H-Index: 25
view all 8 authors...
T-cell memory is an important mechanism for long-term protection against diverse pathogens. Generation and persistence of memory T cells are vital components of anti-tumor immunity, given their ability to persist for prolonged durations, as well as activate and migrate rapidly. In the present study, we investigated the clinical and prognostic significance of T-cell subsets in the peripheral circulation of patients with head and neck squamous cell carcinoma (HNSCC). Moreover, we calculated the en...
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